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l-Naproxen  (Synonyms: (R)-Naproxen)

Cat. No.: HY-15031 Purity: 99.47%
SDS COA Handling Instructions

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l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID).

For research use only. We do not sell to patients.

l-Naproxen Chemical Structure

l-Naproxen Chemical Structure

CAS No. : 23979-41-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of l-Naproxen:

l-Naproxen Related Antibodies

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Description

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID)[1][2][3].

In Vitro

l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in HeLa cells[3].
l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].
l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

l-Naproxen Related Antibodies

Cell Viability Assay[3]

Cell Line: HeLa cells
Concentration: 30-1000 μM
Incubation Time: 2 hour
Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively.

Cell Migration Assay [3]

Cell Line: OvCa429 and OvCa433 cells
Concentration: 0-300 μM
Incubation Time: 48 hour
Result: Inhibited migration of immortalized human ovarian cancer cells at 300 μM.

Western Blot Analysis[3]

Cell Line: OvCa433 cells
Concentration: 300 μM
Incubation Time: 48 hour
Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls.
Molecular Weight

230.26

Formula

C14H14O3
CAS No.
Appearance

Solid

SMILES

COC1=CC=C2C(C=CC([C@H](C(O)=O)C)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (434.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3429 mL 21.7146 mL 43.4292 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

SDS (392 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3429 mL 21.7146 mL 43.4292 mL 108.5729 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL 21.7146 mL
10 mM 0.4343 mL 2.1715 mL 4.3429 mL 10.8573 mL
15 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
20 mM 0.2171 mL 1.0857 mL 2.1715 mL 5.4286 mL
25 mM 0.1737 mL 0.8686 mL 1.7372 mL 4.3429 mL
30 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
40 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7143 mL
50 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL
60 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
80 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
100 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0857 mL
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l-Naproxen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

l-Naproxen23979-41-1(R)-NaproxenOthersanti-tumor activityHeLaOvCa429OvCa433Inhibitorinhibitorinhibit

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