2. GPCR/G Protein Cell Cycle/DNA Damage Apoptosis Stem Cell/Wnt MAPK/ERK Pathway Cytoskeleton
  3. PAK Apoptosis Ras ERK
  4. AZA197

AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts.

For research use only. We do not sell to patients.

AZA197 Chemical Structure

AZA197 Chemical Structure

CAS No. : 1249398-09-1

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Based on 1 publication(s) in Google Scholar

AZA197 Related Antibodies

Top Publications Citing Use of Products

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View All Isoforms
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

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Description

AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts[1].

Molecular Weight

408.58

Formula

C24H36N6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NC(NC(CCCN(CC)CC)C)=NC(NCCC2=CNC3=C2C=CC=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.5 mg/mL (11.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4475 mL 12.2375 mL 24.4750 mL
5 mM 0.4895 mL 2.4475 mL 4.8950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4475 mL 12.2375 mL 24.4750 mL 61.1875 mL
5 mM 0.4895 mL 2.4475 mL 4.8950 mL 12.2375 mL
10 mM 0.2448 mL 1.2238 mL 2.4475 mL 6.1188 mL
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AZA197 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZA1971249398-09-1AZA 197AZA-197PAKApoptosisRasERKp21 activated kinasesExtracellular signal regulated kinasesCdc42 InhibitorXenograft modelColon cancerInhibitorinhibitorinhibit

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