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Results for "

COMT-IN-1

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151388
    hMAO-B/MB-COMT-IN-1

    		Monoamine Oxidase COMT Neurological Disease
    hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD) [1].
    hMAO-B/MB-COMT-IN-1
  • HY-125339
    Ro 41-0960

    		COMT Neurological Disease
    Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor .
    Ro 41-0960
  • HY-100562
    Flopropione

    		5-HT Receptor COMT Neurological Disease
    Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor . Flopropione also as an antispasmodic agent .
    Flopropione
  • HY-162760
    COMT-IN-1

    		COMT Monoamine Oxidase Neurological Disease
    COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice [1].
    COMT-IN-1

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