2. Metabolic Enzyme/Protease Neuronal Signaling
  3. COMT Monoamine Oxidase
  4. COMT-IN-1

COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice.

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COMT-IN-1 Chemical Structure

COMT-IN-1 Chemical Structure

CAS No. : 2987884-27-3

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COMT-IN-1 Related Antibodies

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MAO-A MAO-B

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Description

COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice[1].

IC50 & Target[1]

COMT

0.37 μM (IC50)

MAO-A

95.58 μM (IC50)

MAO-B

58.82 μM (IC50)

Molecular Weight

463.41

Formula

C24H18FN3O6
CAS No.
SMILES

OC1=C([N+]([O-])=O)C=C(/C=C(C(NCC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)=O)\C#N)C=C1O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COMT-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COMT-IN-12987884-27-3COMTMonoamine OxidaseCatechol-O-methyltransferaseMAONitrophenolicorallydopamine metabolic enzymecatechol-O-methyltransferasechelationmetal ionsBBBdopamineParkinson's diseaseInhibitorinhibitorinhibit

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