2. Metabolic Enzyme/Protease Neuronal Signaling
  3. COMT
  4. Ro 41-0960

Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor.

For research use only. We do not sell to patients.

Ro 41-0960 Chemical Structure

Ro 41-0960 Chemical Structure

CAS No. : 125628-97-9

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Description

Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].

Molecular Weight

277.20

Formula

C13H8FNO5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC([N+]([O-])=O)=C(C(O)=C1)O)C2=CC=CC=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (72.15 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6075 mL 18.0375 mL 36.0750 mL
5 mM 0.7215 mL 3.6075 mL 7.2150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6075 mL 18.0375 mL 36.0750 mL 90.1876 mL
5 mM 0.7215 mL 3.6075 mL 7.2150 mL 18.0375 mL
10 mM 0.3608 mL 1.8038 mL 3.6075 mL 9.0188 mL
15 mM 0.2405 mL 1.2025 mL 2.4050 mL 6.0125 mL
20 mM 0.1804 mL 0.9019 mL 1.8038 mL 4.5094 mL
25 mM 0.1443 mL 0.7215 mL 1.4430 mL 3.6075 mL
30 mM 0.1203 mL 0.6013 mL 1.2025 mL 3.0063 mL
40 mM 0.0902 mL 0.4509 mL 0.9019 mL 2.2547 mL
50 mM 0.0722 mL 0.3608 mL 0.7215 mL 1.8038 mL
60 mM 0.0601 mL 0.3006 mL 0.6013 mL 1.5031 mL
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Ro 41-0960 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 41-0960125628-97-9COMTCatechol-O-methyltransferaseInhibitorinhibitorinhibit

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