Cardiolipin

By Targets:	Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (3) Endogenous Metabolite (1) Fluorescent Dye (1) Lactate Dehydrogenase (1) Liposome (2) Mitochondrial Metabolism (3) Reactive Oxygen Species (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Phospholipids (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134238

Cardiolipin (Heart, Bovine) (sodium)	Endogenous Metabolite	Neurological Disease
Cardiolipin (Heart, Bovine) sodium is a mitochondria-exclusive phospholipid. Cardiolipin (Heart, Bovine) sodium has the potential for the research of Neurological Disease .

HY-D0993

Acridine Orange 10-Nonyl Bromide 3 Publications Verification Nonylacridine orange	Fluorescent Dye	Others
Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λ_ex: 489 nm, λ_em: 525 nm).

HY-125857

Cytochrome C	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species	Metabolic Disease
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-P0125

Elamipretide Maximum Cited Publications 12 Publications Verification MTP-131; RX-31; SS-31	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P0125B

Elamipretide triacetate Maximum Cited Publications 12 Publications Verification MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is Elamipretide triacetate form of Elamipretide (HY-P0125). Elamipretide triacetate is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-159856

16:0 Cardiolipin Diphosphatidylglycerol (16:0)	Liposome	Others
16:0 Cardiolipin (Diphosphatidylglycerol (16:0)) is a phospholipid derived from Palmitic acid (16:0) that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .

HY-157661

*14:0 Cardiolipin* sodium** 1',3'-Bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol sodium	Biochemical Assay Reagents
14:0 Cardiolipin sodium (1',3'-Bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium)) is a kind of biochemical reagent.

HY-W590676

Tetramyristoylcardiolipin TMCL	Liposome	Others
Tetramyristoylcardiolipin (TMCL) is an anionic lipid. Tetramyristoylcardiolipin can be used to study cell membrane function and drug delivery .

HY-169160

Anti-MRSA agent 18	Bacterial	Infection
Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death .

HY-116447

Antitumor agent-159	Mitochondrial Metabolism Apoptosis	Cancer
Antitumor agent-159 (Compound 13b) targets the mitochondria and downregulates cardiolipin levels. Antitumor agent-159 inhibits the proliferation of cancer cell MDA-MB-231, arrests the cell cycle at sub-G1 phase, and induces apoptosis in MDA-MB-231. Antitumor agent-159 exhibits antitumor efficacy in MDA-MB-231 xenograft mouse models .

HY-P2807J

L-Lactate Dehydrogenase (L-LDH), pig muscle	Lactate Dehydrogenase	Metabolic Disease
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC₅₀ values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .

HY-W251428

Phosphatidylglycerols (egg) (sodium salt) Egg PG	Biochemical Assay Reagents	Others
Phosphatidylglycerol is a naturally occurring anionic phospholipid that is a component of plant, animal and bacterial cell membranes. It is present in prokaryotes and eukaryotes less than phosphatidylethanolamine, and in eukaryotes less than phosphatidylcholine. It is formed by the reaction between CDP-diglyceride and L-α-glycerol 3-phosphate followed by dephosphorylation and is the metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second-largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and has reduced levels of pulmonary surfactant in infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions. References: [1]. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. Phosphatidylglycerol phosphate synthase-deficient somatic mutants with impaired phosphatidylglycerol and cardiolipin biosynthesis J. Biol. Chemical. 268(30), 22908-22913 (1993).[2]. Furse, S. Are phosphatidylglycerols essential for terrestrial life J. Chemistry. biology. 10(1), 1-9 (2016).[3]. Xie, D., Seremwe, M., Edwards, JG, et al. Different effects of different phosphatidylglycerols on the proliferation of mouse keratinocytes PLoS One 9(9), e107119 (2014).

Cat. No.	Product Name	Type

HY-D0993

Acridine Orange 10-Nonyl Bromide 3 Publications Verification Nonylacridine orange	Fluorescent Dyes/Probes
Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λ_ex: 489 nm, λ_em: 525 nm).

Cat. No.	Product Name	Type

HY-125857

Cytochrome C	Cell Assay Reagents
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W251428

Phosphatidylglycerols (egg) (sodium salt) Egg PG	Drug Delivery
Phosphatidylglycerol is a naturally occurring anionic phospholipid that is a component of plant, animal and bacterial cell membranes. It is present in prokaryotes and eukaryotes less than phosphatidylethanolamine, and in eukaryotes less than phosphatidylcholine. It is formed by the reaction between CDP-diglyceride and L-α-glycerol 3-phosphate followed by dephosphorylation and is the metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second-largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and has reduced levels of pulmonary surfactant in infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions. References: [1]. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. Phosphatidylglycerol phosphate synthase-deficient somatic mutants with impaired phosphatidylglycerol and cardiolipin biosynthesis J. Biol. Chemical. 268(30), 22908-22913 (1993).[2]. Furse, S. Are phosphatidylglycerols essential for terrestrial life J. Chemistry. biology. 10(1), 1-9 (2016).[3]. Xie, D., Seremwe, M., Edwards, JG, et al. Different effects of different phosphatidylglycerols on the proliferation of mouse keratinocytes PLoS One 9(9), e107119 (2014).

Phosphatidylglycerols (egg) (sodium salt)

Egg PG

Drug Delivery

Phosphatidylglycerol is a naturally occurring anionic phospholipid that is a component of plant, animal and bacterial cell membranes. It is present in prokaryotes and eukaryotes less than phosphatidylethanolamine, and in eukaryotes less than phosphatidylcholine. It is formed by the reaction between CDP-diglyceride and L-α-glycerol 3-phosphate followed by dephosphorylation and is the metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second-largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and has reduced levels of pulmonary surfactant in infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions. References: [1]. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. Phosphatidylglycerol phosphate synthase-deficient somatic mutants with impaired phosphatidylglycerol and cardiolipin biosynthesis J. Biol. Chemical. 268(30), 22908-22913 (1993).[2]. Furse, S. Are phosphatidylglycerols essential for terrestrial life J. Chemistry. biology. 10(1), 1-9 (2016).[3]. Xie, D., Seremwe, M., Edwards, JG, et al. Different effects of different phosphatidylglycerols on the proliferation of mouse keratinocytes PLoS One 9(9), e107119 (2014).

HY-157661

*14:0 Cardiolipin* sodium** 1',3'-Bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol sodium	Drug Delivery
14:0 Cardiolipin sodium (1',3'-Bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium)) is a kind of biochemical reagent.

Cat. No.	Product Name	Target	Research Area

HY-P0125

Elamipretide 10+ Cited Publications MTP-131; RX-31; SS-31	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P0125B

Elamipretide triacetate 10+ Cited Publications MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is Elamipretide triacetate form of Elamipretide (HY-P0125). Elamipretide triacetate is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134238

Cardiolipin (Heart, Bovine) (sodium)	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Cardiolipin (Heart, Bovine) sodium is a mitochondria-exclusive phospholipid. Cardiolipin (Heart, Bovine) sodium has the potential for the research of Neurological Disease .

Cat. No.	Compare	Product Name	Species	Source

HY-P702649

	PKN2 Protein, Human (sf9, His, GST) PKN2; protein kinase N2; PRKCL2, protein kinase C like 2; serine/threonine-protein kinase N2; Cardiolipin activated protein kinase Pak2; Pak 2; PRK2; PKN gamma; protein kinase C-like 2; protein-kinase C-related kinase 2; Cardiolipin-activated protein kinase Pak2; PAK2; Pak-2; PRKCL2; PRO2042; MGC71074; MGC150606	Human	Sf9 insect cells
	PKN2 Protein, Human (sf9, His, GST) is the recombinant human-derived PKN2, expressed by Sf9 insect cells , with His, GST labeled tag. ,

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HY-160202

*18:1 Cardiolipin* disodium**		Phospholipids
18:1 Cardiolipin disodium is a virulence regulator with two phosphate groups and four acyl chains.18:1 Cardiolipin disodium can be used in the study of the regulation and mechanism of bacterial infection .

HY-160203

18:0 Cardiolipin		Phospholipids
18:0 Cardiolipin (CL) is a polyglycerophospholipid synthesized in mitochondria, playing a crucial role in mitochondrial bioenergetics and signaling. Exclusively found in the inner mitochondrial membrane of eukaryotes, 18:0 CL exhibits a complex structure characterized by its unique chain length and degree of saturation, along with the specific arrangements of its four fatty acid substituents.

HY-W590676

Tetramyristoylcardiolipin TMCL		Phospholipids
Tetramyristoylcardiolipin (TMCL) is an anionic lipid. Tetramyristoylcardiolipin can be used to study cell membrane function and drug delivery .

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