Phosphatidylglycerols (egg) sodium salt (Synonyms: Egg PG)

Name: Phosphatidylglycerols (egg) sodium salt
Brand: MedChemExpress
SKU: HY-W251428
Rating: 4.5 (1 reviews)

Cat. No.: HY-W251428 Purity: 99.92%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV).

For research use only. We do not sell to patients.

Phosphatidylglycerols (egg) sodium salt Chemical Structure

CAS No. : 383907-64-0

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25 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Phosphatidylglycerol is present in lower amounts than phosphatidylethanolamine in prokaryotes and eukaryotes and in lower amounts than phosphatidylcholine in eukaryotes. Phosphatidylglycerol is formed by the reaction between CDP-diacylglycerol and L-α-glycerol 3-phosphate followed by dephosphorylation and is a metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and levels are reduced in the lung surfactant of infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

783.04

Formula

C₄₂H₈₀NaO₉P

CAS No.

383907-64-0

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(OC[C@](CC(CCCCCCC/C=C\CCCCCCCC)=O)(C)COP(OCC(O)CO)(O[Na])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (12.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2771 mL	6.3854 mL	12.7707 mL
5 mM	0.2554 mL	1.2771 mL	2.5541 mL
10 mM	0.1277 mL	0.6385 mL	1.2771 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.60 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (242 KB) HNMR (244 KB) RP-HPLC (221 KB)

Handling Instructions (2659 KB)

References

[1]. Chen WW, et al. Phosphatidylglycerol Incorporates into Cardiolipin to Improve Mitochondrial Activity and Inhibits Inflammation. Sci Rep. 2018 Mar 20;8(1):4919. [Content Brief]

[2]. Numata M, et al. Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):320-5. [Content Brief]

[3]. Poelma DL, et al. Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function. J Appl Physiol (1985). 2005 May;98(5):1784-91. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2771 mL	6.3854 mL	12.7707 mL	31.9269 mL
	5 mM	0.2554 mL	1.2771 mL	2.5541 mL	6.3854 mL
	10 mM	0.1277 mL	0.6385 mL	1.2771 mL	3.1927 mL

Phosphatidylglycerols (egg) sodium salt Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphatidylglycerols (egg)383907-64-0Egg PGBiochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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Phosphatidylglycerols (egg) sodium salt (Synonyms: Egg PG)

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•Related Small Molecules:

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Biological Activity

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References

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Phosphatidylglycerols (egg) sodium salt Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Phosphatidylglycerols (egg) sodium salt Related Classifications

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