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Pathways Recommended:	Vitamin D Related/Nuclear Receptor
Isoforms Recommended:	Cathepsin D

Results for "

Cathepsin D

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (7) Beta-secretase (5) Isotope-Labeled Compounds (1) SARS-CoV (1)
By Research Areas:	Cancer (6) Infection (3) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (4)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Cathepsin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P2750

Cathepsin D CTSD	Others	Others
Cathepsin D (CTSD) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P2750A

Cathepsin D, Human Liver	Others	Others
Cathepsin D, Human Liver is a glycosylated, lysosomal aspartic proteinase, which is isolated from human liver .

HY-169171

Cathepsin L-IN-5	Cathepsin	Infection
Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC₅₀ of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in infection research .

HY-P4787

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2	Cathepsin	Others
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .

HY-10042S

Odanacatib-d4 MK-0822-d₄	Isotope-Labeled Compounds	Metabolic Disease Cancer
Odanacatib-d4 is the deuterium labeled Odanacatib (HY-10042). Odanacatib is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K .

HY-149680

CatD-P1	Others	Others
CatD-P1is a pH insensitive CatD (Cathepsin D) probe .

HY-148034

Plm IV inhibitor-1	Others	Infection
Plm IV inhibitor-1 (compound 6) is a potent plasmepsin IV (Plm IV) inhibitor with IC₅₀s of 4.1, 0.80, 0.25, 0.35 µM for Plm I, Plm II, Plm IV, Cat D, respectively .

HY-163389

*Mpro/Cathepsin* L-IN-1**	SARS-CoV Cathepsin	Infection
Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M ^pro/hCatL inhibitor, with K_is of 5.54 μM and 0.701 μM respectively .

HY-137978

Ezurpimtrostat GNS561	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .

HY-137978A

Ezurpimtrostat hydrochloride 1 Publications Verification GNS561 hydrochloride	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .

HY-P4561

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

HY-124322

NB-360	Beta-secretase	Neurological Disease Inflammation/Immunology
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC₅₀: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E .

HY-10472

LY2811376 Maximum Cited Publications 11 Publications Verification	Beta-secretase	Neurological Disease
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-13240

LY2886721 2 Publications Verification	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-13240A

LY2886721 hydrochloride	Beta-secretase	Neurological Disease
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-13438

AZD3839 free base 1 Publications Verification	Beta-secretase	Cancer
AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (K_i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4335

Bz-RGFFP-4MβNA	Peptides	Others
Bz-RGFFP-4MβNA, a substrate for *Cathepsin* D, is suitable for either colorimetric or fluorometric assay .

HY-P4787

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2	Cathepsin	Others
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .

HY-P4561

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

Recombinant Proteins Recommended:

Cathepsin D

Species:	Human (2) Mouse (1)
Tag:	SUMO (1) His (4)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72155

	Cathepsin D Protein, Cricetulus griseus (His-SUMO) Cathepsin D; H671_3g9701	Others	E. coli
	Cathepsin D is an intracellular aspartic protease of the pepsin superfamily. Cathepsin D is synthesized on the rough endoplasmic reticulum as a pre-pro-enzyme. Cathepsin D is sorted to the lysosomal compartments mainly by M-6-P pathway. Cathepsin D Protein, Cricetulus griseus (His-SUMO) is the recombinant Cathepsin D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Cathepsin D Protein, Cricetulus griseus (His-SUMO) is 344 a.a., with molecular weight of ~53.3 kDa.

HY-P7749

	Cathepsin D Protein, Mouse (HEK293, His) rMuCathepsin D, His; Cathepsin D; CTSD; CPSD	Mouse	HEK293
	Cathepsin D Protein, Mouse (HEK293, His) is an approximately 56.0 kDa mouse cathepsin D with a His tag. Cathepsin D is a lysosomal aspartic protease of the pepsin family.

HY-P7748

	Cathepsin D Protein, Human (HEK293, His, solution) rHuCathepsin D, His; Cathepsin D; CTSD; CPSD	Human	HEK293
	Cathepsin D Protein, Human (HEK293, His, solution) is an approximately 50.0 kDa cathepsin D protein with a His-flag. Cathepsin D is a representative lysosomal aspartic proteinases and belongs to the peptidase C1 family.

HY-P7748A

	Cathepsin D Protein, Human (HEK293, C-His) rHuCathepsin D, His; Cathepsin D; CTSD; CPSD	Human	HEK293
	Cathepsin D protein is an acidic protease that actively participates in intracellular protein breakdown. Studies have shown that it is critical in the processing of amyloid precursor protein (APP), with ADAM30-mediated cleavage and activation leading to APP degradation. Cathepsin D Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin D Protein, Human (HEK293, C-His) is 392 a.a., with molecular weight of ~44.78 kDa.

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Odanacatib-d4
Odanacatib-d4 is the deuterium labeled Odanacatib (HY-10042). Odanacatib is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K .

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HY-P80384

	Cathepsin D Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse
	Cathepsin D Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 45/28 kDa, targeting to Cathepsin D. It can be used for WB,ICC,IHC-P,IP assays with tag free, in the background of Human, Mouse.

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