Search Result

Results for "

GABA-AT-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GABA Receptor (21) iGluR (1) Isotope-Labeled Compounds (1)
By Research Areas:	Infection (1) Neurological Disease (19)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: GABA Receptor AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147982

*GABA-AT-IN-1*	GABA Receptor	Neurological Disease
GABA-AT-IN-1 (Compound 6) is a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor and significantly elevates the mouse brain GABA level. GABA-AT-IN-1 has the ability to cross the BBB and can be used as an anticonvulsant ^[1].

HY-159504

Pregabalinum naproxencarbilum PreGABAlIN naproxencarbil	GABA Receptor	Neurological Disease
Pregabalinum naproxencarbilum (Pregabalin naproxencarbil) is a gabamimetic (GABA), analgesic compound .

HY-103495

17-PA	GABA Receptor	Neurological Disease
17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABA ^A receptors .

HY-156339

*GABA receptor Antagonist 1*	GABA Receptor	Others
GABA receptor Antagonist 1 (compound 7w) inhibits Px RDL1 GABAR with an IC₅₀ value of 7.08 nmol/L. GABA receptor Antagonist 1 shows insecticide activity against P. xylostella, S. frugiperda, S. exigua, and S. litura, with LC₅₀ of 0.09, 0.84, 0.87, and 0.68 mg/L respectively. GABA receptor Antagonist 1 shows a medium toxicity to honeybee (48 h, ID₅₀ = 2.22 μg/adult), and low toxicity to zebrafish (LC₅₀: 42.4 mg/L) ^[1].

HY-118259

L-663581 FG-8205	GABA Receptor	Neurological Disease
L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor .

HY-129464

NO-711ME	GABA Receptor	Neurological Disease
NO-711ME is a prodrug of NO-711. NO-711 is a potent and selective GABA uptake inhibitor .

HY-N9407

Guvacine ethyl ester	GABA Receptor	Others
Guvacine ethyl ester (3.1b) is an alkaloid that can be found in betel nut. Guvacine ethyl ester can be used in the synthesis of GABA uptake inhibitor .

HY-149399

GABA-IN-1	Others GABA Receptor	Infection
GABA-IN-1 (Compound 6) is a *GABA* inhibitor. GABA-IN-1 has larvicidal activity and insecticidal effect, with mortality rates of 93% at 50 mg/L ^[1].

HY-116152A

(S)-Cipepofol (S)-Ciprofol; (S)-HSK3486	GABA Receptor	Neurological Disease
(S)-Cipepofol is the isomer of Cipepofol (HY-116152).Cipepofol (HSK3486) is a sleep-promoting active molecule and a gamma-aminobutyric acid (GABA) receptor enhancer .

HY-108403

Phenibut β-Phenyl-GABA; 4-AmINo-3-phenylbutanoic acid	GABA Receptor	Neurological Disease
Phenibut (β-Phenyl-GABA) is a *GABA-B* agonist . Phenibut acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut has anxiolytic and nootropic (cognition enhancing) effects .

HY-W041333

Phenibut hydrochloride β-Phenyl-GABA hydrochloride; 4-AmINo-3-phenylbutanoic acid hydrochloride; 4-AmINo-3-phenylbutyric acid hydrochloride	GABA Receptor	Neurological Disease
Phenibut (β-Phenyl-GABA) hydrochloride is an orally active *GABA-B* agonist . Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects .

HY-119591

BPDBA	GABA Receptor	Neurological Disease
BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC₅₀s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively ^[1].

HY-100228A

SKF89976A hydrochloride d,l-SKF89976A hydrochloride	GABA Receptor	Neurological Disease
SKF89976A hydrochloride is a selective *GABA transporter* (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-135034

UMB68 sodium	GABA Receptor	Neurological Disease
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [ ³H]NCS-382 with an IC₅₀ of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds .

HY-100228

SKF 89976A	GABA Receptor	Neurological Disease
SKF89976A is a selective *GABA transporter* (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-103509

NNC 05-2090 hydrochloride	GABA Receptor	Neurological Disease
NNC 05-2090 hydrochloride is a *GABA* uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC_{50< /sub>}: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a K_i value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases ^[1] .

HY-120146

NNC 05-2090	GABA Receptor	Neurological Disease
NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC₅₀ sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a K_i value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases ^[1] .

HY-B0033S

Vigabatrin-13C,d2 hydrochloride γ-VINyl-GABA-¹³C,d₂ hydrochloride	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

HY-135482

GABAA receptor agent 2 TFA	GABA Receptor	Neurological Disease
GABAA receptor agent 2 TFA is a potent and high-affinity GABA_A receptor antagonist with an IC₅₀ of 24 nM (human α1β2γ2 GABA_A-expressing tsA201 cells) and a K_i of 28 nM (rat GABA_A receptors). GABAA receptor agent 2 TFA is inactive against four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3) ^[1].

HY-103534

CI-966 hydrochloride	GABA Receptor	Neurological Disease
CI-966 hydrochloride is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for *hGAT-1, rGAT-1*, respectively. CI-966 hydrochloride shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT-3. CI-966 hydrochloride exhibits anticonvulsant and neuroprotective activities ^[1] .

HY-123240

CI-966	GABA Receptor	Neurological Disease
CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for *hGAT-1, rGAT-1*, respectively. CI-966 shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT-3. CI-966 exhibits anticonvulsant and neuroprotective activities ^[1] .

HY-107717

MNI-caged-NMDA	iGluR	Neurological Disease
MNI-caged-NMDA is a light-sensitive amino acid with rapid release properties suitable for use in the study of fast synaptic receptor mechanisms. MNI-caged-NMDA shows metered release of NMDA receptors, inducing rapid and sustained receptor activation in cerebellar interneurons. MNI-caged-NMDA is able to achieve rapid transient responses and generate large inward currents by local laser photolysis. The use of MNI-caged-NMDA can effectively study neurotransmitter signaling and its inhibitory effects on GABA-A receptors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9407

Guvacine ethyl ester	Alkaloids Structural Classification Classification of Application Fields Areca catechu L. Source classification Other Diseases Pyridine Alkaloids Plants Palmae Disease Research Fields	GABA Receptor
Guvacine ethyl ester (3.1b) is an alkaloid that can be found in betel nut. Guvacine ethyl ester can be used in the synthesis of GABA uptake inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-B0033S

Vigabatrin-13C,d2 hydrochloride
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

Vigabatrin-13C,d2 hydrochloride

Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks