2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Phenibut hydrochloride

Phenibut hydrochloride  (Synonyms: β-Phenyl-GABA hydrochloride; 4-Amino-3-phenylbutanoic acid hydrochloride; 4-Amino-3-phenylbutyric acid hydrochloride)

Cat. No.: HY-W041333 Purity: ≥98.0%
COA Handling Instructions

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Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects.

For research use only. We do not sell to patients.

Phenibut hydrochloride Chemical Structure

Phenibut hydrochloride Chemical Structure

CAS No. : 3060-41-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Phenibut hydrochloride:

Phenibut hydrochloride Related Antibodies

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Description

Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist[1]. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects[2].

IC50 & Target

GABA-B[1][2]
In Vitro

Phenibut hydrochloride is a neuropsychotropic agent. Phenibut hydrochloride also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenibut hydrochloride Related Antibodies
Molecular Weight

215.68

Formula

C10H14ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(C1=CC=CC=C1)CN.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (463.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6365 mL 23.1825 mL 46.3650 mL
5 mM 0.9273 mL 4.6365 mL 9.2730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (245 KB) HNMR (217 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6365 mL 23.1825 mL 46.3650 mL 115.9125 mL
5 mM 0.9273 mL 4.6365 mL 9.2730 mL 23.1825 mL
10 mM 0.4636 mL 2.3182 mL 4.6365 mL 11.5912 mL
15 mM 0.3091 mL 1.5455 mL 3.0910 mL 7.7275 mL
20 mM 0.2318 mL 1.1591 mL 2.3182 mL 5.7956 mL
25 mM 0.1855 mL 0.9273 mL 1.8546 mL 4.6365 mL
30 mM 0.1545 mL 0.7727 mL 1.5455 mL 3.8637 mL
40 mM 0.1159 mL 0.5796 mL 1.1591 mL 2.8978 mL
50 mM 0.0927 mL 0.4636 mL 0.9273 mL 2.3182 mL
60 mM 0.0773 mL 0.3864 mL 0.7727 mL 1.9319 mL
80 mM 0.0580 mL 0.2898 mL 0.5796 mL 1.4489 mL
100 mM 0.0464 mL 0.2318 mL 0.4636 mL 1.1591 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Phenibut hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenibut3060-41-1β-Phenyl-GABA4-Amino-3-phenylbutanoic acid4-Amino-3-phenylbutyric acidGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorneuropsychotropicβ-phenethylaminePEAendogenousanxiogenicInhibitorinhibitorinhibit

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