2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. UMB68 sodium

UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.

For research use only. We do not sell to patients.

UMB68 sodium Chemical Structure

UMB68 sodium Chemical Structure

CAS No. : 581099-89-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

UMB68 sodium Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].

IC50 & Target

GHB receptor[1]
In Vitro

UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].
UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UMB68 sodium Related Antibodies
In Vivo

UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1]
Dosage: 320, 660, 1000, 1778 mg/kg
Administration: I.p. injection
Result: Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
Molecular Weight

154.14

Formula

C6H11NaO3
CAS No.
SMILES

CC(C)(O)CCC(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

UMB68 sodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UMB68581099-89-0UMB 68UMB-68GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGHBNCS-382cerebrocorticalmembranesGABInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
UMB68 sodium
Cat. No.:
HY-135034
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.