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Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .
Misetionamide is an orally oxathiazin-like compound. Misetionamide is a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with antineoplastic activity. Misetionamide can be used for the research of cancer .
Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases . Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM .
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .
Omigapil maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease . Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals .
GAPDH Human Pre-designed siRNA Set A contains three designed siRNAs for GAPDH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
GAPDHS Human Pre-designed siRNA Set A contains three designed siRNAs for GAPDHS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively .
Ddit4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddit4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 µΜ . G6PD activator AG1 reduces hemolysis of human erythrocytes .
SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD .
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
The GAPDH protein has dual roles in glycolysis and nuclear function. It also affects the organization and assembly of the cytoskeleton and promotes the association of microtubules and membranes. GAPDH Protein, Mouse (His) is the recombinant mouse-derived GAPDH protein, expressed by E. coli , with N-6*His labeled tag. The total length of GAPDH Protein, Mouse (His) is 333 a.a., with molecular weight of ~38 kDa.
The GAPDH protein has dual roles in glycolysis and nuclear function. It also affects the organization and assembly of the cytoskeleton and promotes the association of microtubules and membranes. GAPDH Protein, Human (HEK293, His) is the recombinant human-derived GAPDH protein, expressed by HEK293 , with N-6*His labeled tag.
GAPDH, a multifunctional protein, acts as a key enzyme in glycolysis, catalyzing the conversion of G3P. It also functions as a nitrosylase, impacting nuclear processes. In addition, it influences cytoskeleton organization, associates with CHP1, participates in transcript-selective translation inhibition, contributes to immune responses, and mediates nuclear events through S-nitrosylation of target proteins. GAPDH Protein, Human (His-SUMO) is the recombinant human-derived GAPDH protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
GAPDH Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to GAPDH. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat, Chicken.
GAPDH Antibody (HRP) (YA874) is a mouse-derived, anti-GAPDH (HRP) (YA874) monoclonal antibody. GAPDH Antibody (HRP) (YA874) can be used for: WB, ELISA expriments in human, mouse, rat background with HRP labeling.
Human, Monkey, Rat, Mouse, Saccharomyces cerevisiae, Pichia pastoris, Hamster
GAPDH Antibody (YA848) is a non-conjugated and Mouse origined monoclonal antibody about 36 kDa. It can be used for WB assays with tag free, in the background of Human, Monkey, Rat, Mouse, Hamster, Saccharomyces cerevisiae, Pichia pastoris.
Omigapil maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease . Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
GAPDH Human Pre-designed siRNA Set A contains three designed siRNAs for GAPDH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
GAPDHS Human Pre-designed siRNA Set A contains three designed siRNAs for GAPDHS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Ddit4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddit4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
