Sodium iodoacetate (Synonyms: Iodoacetic acid sodium salt)

Cat. No.: HY-D0849 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals.

For research use only. We do not sell to patients.

Sodium iodoacetate Chemical Structure

CAS No. : 305-53-3

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Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 58	In-stock	Estimated Time of Arrival: December 31
10 g	USD 93	In-stock	Estimated Time of Arrival: December 31
25 g	USD 185	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

In Vivo

Sodium iodoacetate (0, 0.3 and 3 mg/joint; injected into the right knee joint space; single dose injection) causes proliferation and moderate fibrosis of synovial cells in Wistar rats, accompanied by mild inflammatory cell infiltration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

207.93

Formula

C₂H₂INaO₂

CAS No.

305-53-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (480.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (480.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8093 mL	24.0466 mL	48.0931 mL
5 mM	0.9619 mL	4.8093 mL	9.6186 mL
10 mM	0.4809 mL	2.4047 mL	4.8093 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (480.93 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (271 KB) SDS (641 KB)

COA (246 KB) HNMR (218 KB) RP-HPLC (240 KB) MS (79 KB)

Handling Instructions (2659 KB)

References

[1]. Xu, Y. et al. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Frontiers in Immunology, 13. [Content Brief]

[2]. Na, H. et al. Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of Translational Medicine, 20(1) [Content Brief]

[3]. Kobayashi K, et al. Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats[J]. Journal of Veterinary Medical Science, 2003, 65(11): 1195-1199. [Content Brief]

[4]. Güler N, et al. Sodium iodoacetate induced osteoarthrosis model in rabbit temporomandibular joint: CT and histological study (part I)[J]. International journal of oral and maxillofacial surgery, 2011, 40(11): 1289-1295. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.8093 mL	24.0466 mL	48.0931 mL	120.2328 mL
	5 mM	0.9619 mL	4.8093 mL	9.6186 mL	24.0466 mL
	10 mM	0.4809 mL	2.4047 mL	4.8093 mL	12.0233 mL
	15 mM	0.3206 mL	1.6031 mL	3.2062 mL	8.0155 mL
	20 mM	0.2405 mL	1.2023 mL	2.4047 mL	6.0116 mL
	25 mM	0.1924 mL	0.9619 mL	1.9237 mL	4.8093 mL
	30 mM	0.1603 mL	0.8016 mL	1.6031 mL	4.0078 mL
	40 mM	0.1202 mL	0.6012 mL	1.2023 mL	3.0058 mL
	50 mM	0.0962 mL	0.4809 mL	0.9619 mL	2.4047 mL
	60 mM	0.0802 mL	0.4008 mL	0.8016 mL	2.0039 mL
	80 mM	0.0601 mL	0.3006 mL	0.6012 mL	1.5029 mL
	100 mM	0.0481 mL	0.2405 mL	0.4809 mL	1.2023 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium iodoacetate Related Classifications

Metabolic Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium iodoacetate305-53-3Iodoacetic acidBiochemical Assay ReagentsOsteoarthritisGlycolysis inhibitionOsteoarthritis modelInhibitorinhibitorinhibit

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