2. Oligonucleotides
  3. Cationic Lipids

Cationic Lipids

The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.

Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.

Cationic Lipids (192):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112251
    D-Lin-MC3-DMA 1224606-06-7 99.68%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
    D-Lin-MC3-DMA
  • HY-134541
    SM-102 2089251-47-6 99.90%
    SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
    SM-102
  • HY-138170
    ALC-0315 2036272-55-4 99.81%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
    ALC-0315
  • HY-112754A
    DOTAP chloride 132172-61-3 ≥98.0%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
    DOTAP chloride
  • HY-145405
    C12-200 1220890-25-4 99.91%
    C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B.
    C12-200
  • HY-165029
    1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC 17708-90-6
    1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) is a phospholipid used as a major component in lipid bilayer system models. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC can serve as an untreated control, mixed with oxidized lipids such as 1-palmitoyl-2-(13-hydroxy-9,11-octadecanedienoyl)-lecithin (OHPLPC) and 1-palmitoyl-2-(13-hydroperoxy-9,11-octadecanedienoyl)-lecithin (HpPLPC), to study the effects of oxidation on membrane properties.
    1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC
  • HY-159700
    AA3-DLin 3027565-91-6
    AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model.
    AA3-DLin
  • HY-167015
    1O14
    1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes.
    1O14
  • HY-145799
    5A2-SC8 1857341-90-2 99.19%
    5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models.
    5A2-SC8
  • HY-112758
    DLin-KC2-DMA 1190197-97-7 99.88%
    DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
    DLin-KC2-DMA
  • HY-130751
    DODAP 127512-29-2 ≥98.0%
    DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation.
    DODAP
  • HY-46760
    CCD Lipid01 1799316-64-5 99.78%
    CCD Lipid01 is a cationic lipid useful in the delivery of biologically active agents to cells and tissues (extracted from patent WO2015095340 A1).
    CCD Lipid01
  • HY-148559
    4A3-SC8 1857340-78-3 99.21%
    4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model.
    4A3-SC8
  • HY-148842
    C14-4 2639634-80-1 99.01%
    C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity.
    C14-4
  • HY-134781
    CKK-E12 1432494-65-9 ≥98.0%
    CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
    CKK-E12
  • HY-139200
    DOTMA 104872-42-6 ≥98.0%
    DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo.
    DOTMA
  • HY-138171
    Lipid 5 2089251-33-0 99.50%
    Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
    Lipid 5
  • HY-151507
    306Oi10 2322290-93-5 ≥98.0%
    306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery.
    306Oi10
  • HY-152229
    G0-C14 1510653-27-6 ≥98.0%
    G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.
    G0-C14
  • HY-112755
    DODMA 104162-47-2 99.60%
    DODMA, a cationic lipid, is used for the preparation of liposomes.
    DODMA