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Results for "

HDAC ligand

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-132998
    HDAC6 degrader-1

    		PROTACs Others
    HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation .
    HDAC6 degrader-1
  • HY-131961
    Triciferol

    		VD/VDR HDAC Cancer
    Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities .
    Triciferol
  • HY-150859
    HDAC ligand-1

    		HDAC Cancer
    HDAC ligand-1 is a HDAC ligand that can be used to synthesize PROTAC HDAC degraders .
    HDAC ligand-1
  • HY-163921
    HDAC8-IN-11

    		Ligands for Target Protein for PROTAC Cancer
    HDAC8-IN-11 is a ligand for target protein for pROTAC.
    HDAC8-IN-11
  • HY-163846
    HDAC8-IN-10

    		HDAC Cancer
    HDAC8-IN-10 (compound 15) is a potent inhibitor of HDAC8, with the IC50 of 7.6 nM. HDAC8-IN-10 is a HDAC8 target protein ligand that can be used to synthesize PROTAC YX862 (HY-163845) .
    HDAC8-IN-10
  • HY-123971
    HDAC6 degrader-4

    		HDAC PROTACs Cancer
    HDAC6 degrader-4 is a PROTAC and a selective HDAC6 degrader consists of a non-selective HDAC inhibitor and thalidomide-type E3 ligase ligand. HDAC6 degrader-4 can be used for cancer research .
    HDAC6 degrader-4
  • HY-163845
    YX862

    		HDAC Cancer
    YX862 is a selective HDAC8 degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells(Sturcture Note:(Blue: VHL E3 ligand (HY-112078), Black: linker；Pink: HDAC8 inhibitor (HY-163846)) .
    YX862

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