2. Vitamin D Related/Nuclear Receptor Epigenetics Cell Cycle/DNA Damage
  3. VD/VDR HDAC
  4. Triciferol

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

For research use only. We do not sell to patients.

Triciferol Chemical Structure

Triciferol Chemical Structure

CAS No. : 957214-00-5

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5 mg USD 1800 In-stock
10 mg USD 3000 In-stock
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Based on 1 publication(s) in Google Scholar

Triciferol Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].

In Vitro

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells[1].
Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triciferol Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB231 breast cancer cells
Concentration: 0-10000 nM
Incubation Time: 0-72 hours
Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.
Molecular Weight

429.59

Formula

C26H39NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C[C@@H](O)C[C@H](O)C/3)/C=C(C)/C=C/C(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3278 mL 11.6390 mL 23.2780 mL
5 mM 0.4656 mL 2.3278 mL 4.6556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.61%

COA (245 KB) HNMR (383 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3278 mL 11.6390 mL 23.2780 mL 58.1950 mL
5 mM 0.4656 mL 2.3278 mL 4.6556 mL 11.6390 mL
10 mM 0.2328 mL 1.1639 mL 2.3278 mL 5.8195 mL
15 mM 0.1552 mL 0.7759 mL 1.5519 mL 3.8797 mL
20 mM 0.1164 mL 0.5820 mL 1.1639 mL 2.9098 mL
25 mM 0.0931 mL 0.4656 mL 0.9311 mL 2.3278 mL
30 mM 0.0776 mL 0.3880 mL 0.7759 mL 1.9398 mL
40 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4549 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1639 mL
60 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7274 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5820 mL
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Triciferol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triciferol957214-00-5VD/VDRHDACVitamin DVitamin D receptorHistone deacetylasestubulinhyperacetylationhistoneacetylationantiproliferativeligandInhibitorinhibitorinhibit

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