2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. YX968

YX968 is a potent and selective HDAC3/8 dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis.

For research use only. We do not sell to patients.

YX968 Chemical Structure

YX968 Chemical Structure

CAS No. : 2742732-92-7

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YX968 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

YX968 is a potent and selective HDAC3/8 dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1].

IC50 & Target

HDAC3

1.7 nM (DC50)

HDAC8

6.8 nM (DC50)

In Vitro

YX968 (1 μM, 24 h) can induce cell apoptosis by blocking G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YX968 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0.063, 0.25, 1, 4, 16, 64 μM
Incubation Time: 16 h
Result: CASP3 cleavage (activation) was induced by YX968 in a dose-dependent manner.
Molecular Weight

831.12

Formula

C45H66N8O5S
CAS No.
SMILES

CCCNNC(C(C=C1)=CC=C1N(CC2)CCN2CCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YX968 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YX9682742732-92-7YX 968YX-968HDACApoptosisHistone deacetylasesDegraderMDA-MB-231Inhibitorinhibitorinhibit

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