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Hyaluronan

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By Targets:	Androgen Receptor (2) Bacterial (1) Cytochrome P450 (2) Endogenous Metabolite (1) Estrogen Receptor/ERR (2) Isotope-Labeled Compounds (1) Thyroid Hormone Receptor (2)
By Research Areas:	Cancer (2) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (2)
Oligonucleotides:	Polymers (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Endogenous Metabolite Bacterial	Cancer
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-B1234

Octinoxate Octyl methoxycinnamate	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450	Metabolic Disease Endocrinology
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-B1234S

Octinoxate-13C,d3	Cytochrome P450 Thyroid Hormone Receptor Androgen Receptor Estrogen Receptor/ERR Isotope-Labeled Compounds	Metabolic Disease Endocrinology
Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Cat. No.	Product Name	Type

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Drug Delivery
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

Cat. No.	Product Name	Target	Research Area

HY-P5352

Hyaluronan-IN-1	Peptides	Others
Hyaluronan-IN-1 is a biological active peptide. (This 12 amino acids peptide is a hyaluronan inhibitor (HA), a high molecular weight glycosaminoglycan expressed abundantly in the extracellular matrix and on cell surfaces. This peptide shows specific binding to soluble, immobilized, and cell-associated forms of HA, and it inhibits leukocyte adhesion to HA substrates almost completely.)

HY-P5351

Hyaluronan-binding peptide, biotin labeled	Peptides	Others
Hyaluronan-binding peptide, biotin labeled is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.)

HY-P10403

IGFBP-3 peptide	Peptides	Inflammation/Immunology Cancer
IGFBP-3 peptide is a 18-amino acid insulin-like growth factor binding protein-3. IGFBP-3 peptide binds Humanin (HY-P1928) and Hyaluronan (HY-B0633A), blocks the interaction of CD44 and hyaluronan .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Structural Classification Zea mays L. Classification of Application Fields Source classification Moisture Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Microorganisms Gramineae Cosmetic Research Disease Research Fields Saccharides Cancer	Endogenous Metabolite Bacterial
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Source classification Other Diseases Cosmetic Research Plants Disease Research Fields	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Species:	Human (4) Mouse (1)
Tag:	His (6)
Source:	HEK293 (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P79168

	Hyaluronan Lyase Protein, S. agActiae (His) Hyaluronidase; SAG1197	Others	E. coli
	Hyaluronan Lyase Protein, S. agActiae (His) is the recombinant Hyaluronan Lyase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Hyaluronan Lyase Protein, S. agActiae (His) is 814 a.a., with molecular weight of ~85 kDa.

HY-P70832

	HABP2 Protein, Human (HEK293, His) 2 Publications Verification Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma Hyaluronan-binding protein	Human	HEK293
	HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76379

	HAPLN1 Protein, Human (HEK293, His) Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; HAPLN1; CRTL1	Human	HEK293
	HAPLN1 protein is vital in stabilizing proteoglycan monomer aggregates in cartilage's extracellular matrix. Through interaction with hyaluronic acid, it ensures structural integrity and stability, facilitating proteoglycan binding and organization. HAPLN1's role is crucial for maintaining the extracellular environment, providing proper support and resilience in cartilage tissues. HAPLN1 Protein, Human (HEK293, His) is the recombinant human-derived HAPLN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAPLN1 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of ~52 KDa.

HY-P72222

	HAS2 Protein, Mouse (His) Has2; Hyaluronan synthase 2; EC 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2	Mouse	E. coli
	The HAS2 protein adds GlcNAc or GlcUA monosaccharides to hyaluronic acid, playing a crucial role in its synthesis. HAS2 Protein, Mouse (His) is the recombinant mouse-derived HAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HAS2 Protein, Mouse (His) is 308 a.a., with molecular weight of ~39.9 kDa.

HY-P70407

	ITIH3 Protein, Human (HEK293, His) rHuInter-alpha-trypsin inhibitor heavy chain H3/ITIH3/, His; Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; Serum-derived Hyaluronan-associated protein; SHAP	Human	HEK293
	The ITIH3 protein has a dual role: as a carrier of hyaluronic acid in serum and as a binding protein that facilitates interactions with various matrix proteins. These interactions regulate the localization, synthesis, and degradation of hyaluronic acid, which is critical for multiple cellular activities. ITIH3 Protein, Human (HEK293, His) is the recombinant human-derived ITIH3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P79135

	Stabilin-2 Protein, Human (His) Stabilin-2; STAB2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; FEEL2; FELL; FEX2; HARE	Human	E. coli
	Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

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HY-B1234S

Octinoxate-13C,d3
Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83060

	HAPLN1 Antibody (YA2805) Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Cartilage-link protein; Proteoglycan link protein; HAPLN1; CRTL1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	HAPLN1 Antibody (YA2805) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2805), targeting HAPLN1, with a predicted molecular weight of 40 kDa (observed band size: 48 kDa). HAPLN1 Antibody (YA2805) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82566

	GC1q R Antibody (YA2311) C1QBP; GC1QBP; HABP1; SF2P32; Complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33	WB, IP	Human, Mouse, Rat
	GC1q R Antibody (YA2311) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2311), targeting GC1q R, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). GC1q R Antibody (YA2311) can be used for WB, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate		Polymers
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

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Hyaluronan

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

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