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Stabilin-2 Protein, Human (His)

Cat. No.: HY-P79135
COA Handling Instructions

Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

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  • Biological Activity

  • Technical Parameters

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  • Documentation

Description

Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

Background

Stabilin-2 Protein serves as a multifunctional phosphatidylserine receptor, facilitating the engulfment of apoptotic cells, and functions as a hyaluronan receptor, mediating the endocytosis of hyaluronic acid (HA). Additionally, it acts as a primary systemic scavenger receptor, binding to various ligands such as heparin, chondroitin sulfate, dermatan sulfate, non-glycosaminoglycan molecules, acetylated low-density lipoprotein, pro-collagen propeptides, and advanced glycation end products. Stabilin-2 may play a crucial role in maintaining tissue integrity through support for extracellular matrix turnover and contribute to the fluidity of bodily liquids by resorbing hyaluronan. This receptor also functions as a counter receptor, facilitating lymphocyte recruitment in the hepatic vasculature, and displays the ability to bind Gram-positive and Gram-negative bacteria, potentially playing a role in defense against bacterial infection. The proteolytically processed 190 kDa form of Stabilin-2 serves as an endocytosis receptor for heparin internalization, hyaluronan, and chondroitin sulfate. Interactions with GULP1, heparin, alpha-M/beta-2 integrin, and thymosin beta 4 further underscore the diverse functions of Stabilin-2.

Biological Activity

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED50 for this effect is 0.09732 nM.

  • Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED50 for this effect is 0.09732 nM.
Species

Human

Source

E. coli

Tag

C-6*His

Accession

Q8WWQ8 (G2198-V2295)

Gene ID
Molecular Construction
N-term
Stabilin-2 (G2198-V2295)
Accession # Q8WWQ8
His
C-term
Synonyms
Stabilin-2; STAB2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; FEEL2; FELL; FEX2; HARE
AA Sequence

GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDV

Molecular Weight

Approximately 12 kDa

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Stabilin-2 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Stabilin-2 Protein, Human (His)
Cat. No.:
HY-P79135
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