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LDL oxidation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Bacterial (3) Biochemical Assay Reagents (1) Drug Metabolite (1) Endogenous Metabolite (5) Glutathione Peroxidase (1) LDLR (1) NF-κB (1) Reactive Oxygen Species (1)
By Research Areas:	Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (9) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W778608

Quercetin 7-glucuronide Quercetin 7-O-β-glucuronide	Drug Metabolite	Inflammation/Immunology
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation .

HY-120651

LDL-IN-2	LDLR	Metabolic Disease
LDL-IN-2 (compound 3) is an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation .

HY-N0339

Syringic acid	Endogenous Metabolite Bacterial	Metabolic Disease
Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation.

HY-118486

LDL-IN-1	Acyltransferase	Metabolic Disease
LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC₅₀ = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC₅₀s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research .

HY-N3596

Cleomiscosin C Aquillochin	Others	Inflammation/Immunology
Cleomiscosin C (Aquillochin) can be isolated from Aquilaria agallocha. Cleomiscosin C has antioxidant activity. Cleomiscosin C inhibits LDL oxidation and free radicals generation .

HY-N10638

N-Acetyldopamine dimer-2	Reactive Oxygen Species NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .

HY-119265

LDL-IN-4	Acyltransferase	Metabolic Disease
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC₅₀ of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .

HY-N0339S

Syringic acid-d6	Bacterial Endogenous Metabolite	Metabolic Disease
Syringic acid-d₆ is the deuterium labeled Syringic acid[1]. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation[2][3].

HY-123016A

(±)9-HODE cholesteryl ester	Endogenous Metabolite	Metabolic Disease
(±)9-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL.2 Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 9-HODE cholesteryl ester.

HY-N0339R

Syringic acid (Standard)	Endogenous Metabolite Bacterial	Metabolic Disease
Syringic acid (Standard) is the analytical standard of Syringic acid. This product is intended for research and analytical applications. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation.

HY-W747575

(+/-)13-HODE cholesteryl ester	Endogenous Metabolite	Metabolic Disease
(±)13-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.

HY-167870

Piceatannol 4'-O-glucoside	Others	Inflammation/Immunology
Piceatannol 4'-O-glucoside is an antioxidant. Piceatannol 4'-O-glucoside is active against oxidation of the human LDL. Piceatannol 4'-O-glucoside can be isolated from Mexican Bamboo .

HY-113269

alpha-CEHC	Others	Others
alpha-CEHC is a water-soluble metabolite of alpha-tocopherol (α-TOH) with potential antioxidant activity. alpha-CEHC slightly inhibits macrophage-induced low-density lipoprotein (LDL) oxidation, and its inhibitory potency is concentration-dependent .

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Others	Inflammation/Immunology
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .

HY-125039

N-Acetyl lysyltyrosylcysteine amide 2 Publications Verification	Glutathione Peroxidase	Cardiovascular Disease Neurological Disease
N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation .

HY-P1997

Ferrichrome Iron-free Desferrichrome; DFC; N-Desferriferrichrome	Biochemical Assay Reagents	Others
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

HY-137390A

(3S,5R)-Fluvastatin potassium	Others	Cardiovascular Disease Metabolic Disease
(3S,5R)-Fluvastatin (potassium) is a synthetic hypolipidemic drug that inhibits HMG-CoA reductase activity. (3S,5R)-Fluvastatin (potassium) has similar antioxidative effects on copper ion-induced LDL oxidation compared to its 3R,5S enantiomer. (3S,5R)-Fluvastatin (potassium) and its metabolites demonstrate a potential to exhibit anti-atherosclerotic effects through their antioxidative activities. (3S,5R)-Fluvastatin (potassium) is clinically utilized as part of a racemic mixture for reducing plasma cholesterol levels.

Cat. No.	Product Name	Target	Research Area

HY-P1997

Ferrichrome Iron-free Desferrichrome; DFC; N-Desferriferrichrome	Biochemical Assay Reagents	Others
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W778608

Quercetin 7-glucuronide Quercetin 7-O-β-glucuronide	Structural Classification Flavonols Flavonoids Source classification Pedaliaceae Plants Uncarina grandidieri (Baill.) Ihlenf. & Straka	Drug Metabolite
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation .

HY-N0339

Syringic acid	Structural Classification Monophenols Microorganisms other families Classification of Application Fields Source classification Phenols Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial
Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation.

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Others
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .

HY-N3596

Cleomiscosin C Aquillochin	Structural Classification Thymelaeaceae Source classification Phenols Polyphenols Plants Aquilaria sinensis (Lour.) Spreng.	Others
Cleomiscosin C (Aquillochin) can be isolated from Aquilaria agallocha. Cleomiscosin C has antioxidant activity. Cleomiscosin C inhibits LDL oxidation and free radicals generation .

HY-N0339R

Syringic acid (Standard)	Structural Classification Monophenols Microorganisms other families Source classification Phenols Plants Endogenous metabolite	Endogenous Metabolite Bacterial
Syringic acid (Standard) is the analytical standard of Syringic acid. This product is intended for research and analytical applications. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation.

HY-167870

Piceatannol 4'-O-glucoside	Structural Classification Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants	Others
Piceatannol 4'-O-glucoside is an antioxidant. Piceatannol 4'-O-glucoside is active against oxidation of the human LDL. Piceatannol 4'-O-glucoside can be isolated from Mexican Bamboo .

Cat. No.	Product Name	Chemical Structure

HY-N0339S

Syringic acid-d6
Syringic acid-d₆ is the deuterium labeled Syringic acid[1]. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation[2][3].

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LDL oxidation

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products