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Results for "

MBL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (15) Beta-lactamase (13) Endogenous Metabolite (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Infection (16) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129629

Thiomandelic acid	Beta-lactamase Bacterial	Infection Inflammation/Immunology
Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases .

HY-162493

MBL-IN-3	Bacterial	Infection
MBL-IN-3 (compound 72922413) is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor(IC₅₀=54±4 μM). MBL-IN-3 is identified and shown to lower minimum inhibitory concentrations (MICs) of Meropenem (HY-13678) for a panel of E. coli and K. pneumoniae clinical isolates expressing NDM-1. MBL-IN-3 can be used for antibiotic sensitizer research .

HY-158375

MBL-IN-4	Beta-lactamase Bacterial	Infection
MBL-IN-4 (compound 4b) is a *MBL* inhibitor with the IC₅₀ of 4.81 and 33 μM against IMP-1 and NDM-1 .

HY-155104

MBL-IN-1	Beta-lactamase Bacterial	Infection
MBL-IN-1 (compound 41) is a β-Lactamase inhibitor, with the IC₅₀ ranging from 0.10 to 25.85 µM. MBL-IN-1 can be used for research of bacterial infections .

HY-162174

MBL-IN-2	Beta-lactamase Bacterial	Infection
MBL-IN-2 ((2R, 2R')-5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC₅₀ of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used for the study of resistance to β-lactam antibiotics .

HY-RS08188

MBL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MBL2 Human Pre-designed siRNA Set A MBL2 Human Pre-designed siRNA Set A

HY-113590

FR295389	Bacterial	Infection
FR295389 is a dihydroimidazopyrazolium cephalosporin with antibacterial activity. FR295389 shows activity against IMP-type metallo-β-lactamases (MBL)-producing Klebsiella pneumoniae, Acinetobacter baumanii and Pseudomonas putida with MIC values ranging from 4 to 32 mg/mL .

HY-161310

Metallo-β-lactamase-IN-15	Beta-lactamase	Infection
Metallo-β-lactamase-IN-15 (Compound ±13) is a potent *MBL* inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively .

HY-149929

EBL-3183	Beta-lactamase Bacterial	Infection
EBL-3183, an indole-2-carboxylate, is a potent metallo-β-lactamase (MBL) inhibitor. EBL-3183 is reversibly binding, non-covalent, competitive NDM-1 inhibitor with a pIC₅₀ of 7.7 .

HY-144659

Metallo-β-lactamase-IN-5	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-152105

Metallo-β-lactamase-IN-9	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC₅₀s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively .

HY-155201

YJ182	Bacterial	Infection
YJ182 is a NDM-1 inhibitor (IC₅₀: 0.23 μM). YJ182 also inhibits IMP-1, VIM-2, GIM-1, and MMP-2, with IC₅₀s of 0.25, 0.61, 0.49, and 6.92 μM respectively. YJ182 can be used for bacterial infection research .

HY-129200

Aspergillomarasmine A	Endogenous Metabolite	Others
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-144259

Metallo-β-lactamase-IN-2	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively .

HY-144262

Metallo-β-lactamase-IN-4	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively .

HY-144261

Metallo-β-lactamase-IN-3	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC₅₀ of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 .

HY-155504

Metallo-β-lactamase-IN-11	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC₅₀=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance .

HY-143414

Metallo-β-lactamase-IN-6	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC₅₀s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

Species:	Human (2) Mouse (2) Rat (1)
Tag:	His (3) Tag Free (1) Avi (1) Fc (1)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70281

	MBL2/COLEC1 Protein, Human (HEK293, His) rHuMannose-binding protein C/MBL-2, His; Mannose-Binding Protein C; MBP-C; Collectin-1; MBP1; Mannan-Binding Protein; Mannose-Binding Lectin; MBL2; COLEC1; MBL	Human	HEK293
	The MBL2/COLEC1 protein is a calcium-dependent lectin in innate immune defense that activates the lectin complement pathway by binding to mannose, fucose, and N-acetylglucosamine on microorganisms. MBL2/COLEC1 Protein, Human (HEK293, His) is the recombinant human-derived MBL2/COLEC1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MBL2/COLEC1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~31.0 kDa.

HY-P70674

	MBL2/COLEC1 Protein, Mouse (HEK293) Mannose binding lectin (C); isoform CRA_b; Mannose-binding protein C; MBL2; MBL-2; Mannose Binding Lectin 2	Mouse	HEK293
	C-type lectin domain-containing protein is a soluble mannose-binding protein in serum which belongs to the collectin family and is an important element in the innate immune system. C-type lectin domain-containing protein exerts mannose-binding, calcium-dependent protein binding and identical protein binding activity. MBL2/COLEC1 Protein, Mouse (HEK293) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293 , with tag free.

HY-P76488

	MBL1 Protein, Mouse (HEK293, His) Mannose-binding protein A; MBP-A; RaRF p28B	Mouse	HEK293
	MBL1, a calcium-dependent lectin, recognizes microbial moieties, activating the lectin complement pathway.It also binds apoptotic and necrotic cells, aiding uptake by macrophages.As a homotrimer, MBL1 forms higher oligomeric complexes in the endoplasmic reticulum.MBL1's interaction with MASP1 and MASP2 enhances its role in immune response modulation and cellular recognition.MBL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MBL1 protein, expressed by HEK293 , with N-His, N-6*His labeled tag.

HY-P77079

	MBL1 Protein, Rat (HEK293, Fc) Mannose-binding protein A; MBP-A; RaRF p28B	Rat	HEK293
	MBL1 protein is a calcium-dependent lectin that participates in innate immunity by binding to mannose, fucose and N-acetylglucosamine on microorganisms and activating the lectin complement pathway.MBL1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived MBL1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78098

	CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; CD93; C1QR1; MXRA4; ECSM3; dJ737E23.1	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) .Its interaction with these immune factors suggests a role in coordinating the innate immune response.CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD93/C1qR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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MBL2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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