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Results for "

PKA-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PKA (14) Akt (4) Apoptosis (1) CDK (1) ERK (2) G Protein-coupled Receptor Kinase (GRK) (1) p38 MAPK (2) Pim (1) PKC (2) PPAR (2) Ras (1) Serpin (1) SphK (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: PKA AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115732

*PKA-IN-1*	PKA	Inflammation/Immunology
PKA-IN-1 is a potent and selective cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor with an IC₅₀ of 0.03 μM ^[1].

HY-112465

H-8 dihydrochloride	PKA	Cancer
H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive *PKA* inhibitor .

HY-P1595A

CREBtide TFA	PKA	Metabolic Disease
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate .

HY-N2180

Pinoresinol dimethyl ether (+)-EudesmIN	PKC PKA	Neurological Disease
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .

HY-148868

Akt1&PKA-IN-1	Akt PKA CDK	Others
Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC₅₀ values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2) ^[1].

HY-123520

GSK299115A	G Protein-coupled Receptor Kinase (GRK) PKA	Cancer
GSK299115A is a G Protein-coupled Receptor Kinase (GRK) and *PKA* inhibitor .

HY-P10098

PKA Substrate	PKA	Cancer
PKA Substrate is a potent and selective substrate peptide of PKA that can be used to detect PKA activity .

HY-P3920

Cys-Kemptide	PKA	Cancer
Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity .

HY-134298

8-CPT-6-Phe-cAMP 8-(4-Chlorophenylthio)-N6-phenyl-cAMP	PKA	Others
8-CPT-6-Phe-cAMP is an analogue of signal molecule cAMP and a potent protein kinase A (PKA) activator .

HY-P3745

H1-7 (histone H1 phosphorylation site), PKA Substrate	PKA	Others
H1-7 (histone H1 phosphorylation site), PKA Substrate, a synthetic polypeptide, can be used as PKA substrate .

HY-136172

ESI-08 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both *EPAC1* and EPAC2 (IC₅₀ of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation .

HY-143898

PIM1-IN-4	Pim	Cancer
PIM1-IN-4 (Compound 8) is a potent inhibitor of *PIM1. PIM1-IN-4 reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM1*-IN-4 has the potential for the research of cancer diseases ^[1].

HY-N2180R

Pinoresinol dimethyl ether (Standard)	PKC PKA	Neurological Disease
Pinoresinol dimethyl ether (Standard) is the analytical standard of Pinoresinol dimethyl ether. This product is intended for research and analytical applications. Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .

HY-110077

API-1	Akt Apoptosis	Cancer
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC₅₀ of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL) ^[1] .

HY-119016

SK1-I 1 Publications Verification BML-258	SphK	Cancer
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive *SPHK1* inhibitor with a K_i value of 10 µM ^[1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .

HY-119016A

SK1-I hydrochloride 1 Publications Verification BML-258 hydrochloride	SphK	Cancer
SK1-I hydrochloride (BML-258 hydrochloride), an analog of sphingosine, is an isozyme-specific competitive *SPHK1* inhibitor with a K_i value of 10 µM ^[1]. SK1-I hydrochloride shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I hydrochloride enhances autophagy and has antitumor activity .

HY-107544

8-pCPT-2'-O-Me-cAMP-AM	PKA	Metabolic Disease
8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with *PKA* pathway .

HY-N2118

Bilobetin 1 Publications Verification	PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and *PKA* activity .

HY-N2118R

Bilobetin (Standard)	PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-P10336

Serpinin	Serpin	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function ^[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .

Cat. No.	Product Name	Target	Research Area

HY-P1595A

CREBtide TFA	PKA	Metabolic Disease
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate .

HY-P10098

PKA Substrate	PKA	Cancer
PKA Substrate is a potent and selective substrate peptide of PKA that can be used to detect PKA activity .

HY-P3920

Cys-Kemptide	PKA	Cancer
Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity .

HY-P3745

H1-7 (histone H1 phosphorylation site), PKA Substrate	PKA	Others
H1-7 (histone H1 phosphorylation site), PKA Substrate, a synthetic polypeptide, can be used as PKA substrate .

HY-P10336

Serpinin	Serpin	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function ^[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .

Pinoresinol dimethyl ether (+)-EudesmIN	Structural Classification Neurological Disease Classification of Application Fields Magnoliaceae Source classification Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Disease Research Fields	PKC PKA
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .

Bilobetin 1 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Biflavones Ginkgo biloba Disease Research Fields	PPAR PKA Akt p38 MAPK ERK
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and *PKA* activity .

Pinoresinol dimethyl ether (Standard)	Structural Classification Magnoliaceae Source classification Lignans Phenylpropanoids Magnolia biondii Pamp. Plants	PKC PKA
Pinoresinol dimethyl ether (Standard) is the analytical standard of Pinoresinol dimethyl ether. This product is intended for research and analytical applications. Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .

Bilobetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba	PPAR PKA Akt p38 MAPK ERK
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

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PKA-IN-1

Inhibitors & Agonists

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Natural
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