f
  2. Signaling Pathways
  3. Serpin

Serpin

Serine protease inhibitors (Serpins)

Serine protease inhibitors (serpins) are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. Serpins can be divided into two categories. Clade A serpins include inflammatory response molecules such as SERPINA1 (antitrypsin), SERPINA3 (antichymotrypsin), SERPINA6 (corticosteroid-binding globulin), and SERPINA7 (thyroxine-binding globulin). Clade B includes inhibitory molecules such as SERPINB6(PI6), SERPINB9 (PI9), SERPINB3, (squamous cell carcinoma antigen-1), and SERPINB5 (maspin). Serines control crucial physiological processes, such as inflammation, coagulation, thrombosis and thrombolysis, and immune responses[1].

Serpin Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134858
    A1AT modulator 1
    		Inhibitor 99.77%
    A1AT modulator 1 is a potent inhibitor of Z ai-antitrypsin polymerisation with a pIC50 value of 8.3 .
    A1AT modulator 1
  • HY-134863
    A1AT modulator 2
    		Modulator 98.32%
    A1AT modulator 2 (compound 33) is a modulator of A1AT (α-1 antitrypsin) with an IC50 value of ＞1.0 μM and an EC50 value of ＜0.4 μM. A1AT modulator 2 can be used for the research of infection and inflammation.
    A1AT modulator 2
  • HY-P10336
    Serpinin
    		Agonist
    Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects.
    Serpinin