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Pathways Recommended: PROTAC
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PROTAC KSP-IN-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168725
    PROTAC KSP-IN-1

    		PROTACs Kinesin Apoptosis Cancer
    PROTAC KSP-IN-1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP-IN-1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP-IN-1 exhibits antitumor efficacy in mouse model . (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))
    PROTAC KSP-IN-1
  • HY-168727
    KSP ligand 1

    		Kinesin Cancer
    KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research .
    KSP ligand 1

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