PROTAC KSP-IN-1

Cat. No.: HY-168725: FAQs
Data Sheet Handling Instructions

Molarity Calculator

PROTAC KSP-IN-1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC₅₀ of 114.8 nM. PROTAC KSP-IN-1 inhibits the proliferation of HCT-116 with IC₅₀ of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP-IN-1 exhibits antitumor efficacy in mouse model. (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))

For research use only. We do not sell to patients.

PROTAC KSP-IN-1 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC KSP-IN-1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC₅₀ of 114.8 nM. PROTAC KSP-IN-1 inhibits the proliferation of HCT-116 with IC₅₀ of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP-IN-1 exhibits antitumor efficacy in mouse model^[1]. (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))

IC₅₀ & Target

KSP

114.8 nM (DC₅₀)

Molecular Weight

858.01

Formula

C₄₈H₅₁N₅O₈S

SMILES

O=C(NCCCCCCCCNC(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)=O)[C@@H](N)CSC4(C5=CC=C(OC)C=C5)C6=CC=CC=C6C=CC7=C4C=CC=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao DG, et al., Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo. Eur J Med Chem. 2025 Jan 15;282:117052. [Content Brief]

PROTAC KSP-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC KSP-IN-1PROTACsKinesinApoptosisHCT-116BALB/c mouseInhibitorinhibitorinhibit

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