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Pathways Recommended: PROTAC
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PROTAC YAP degrader-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168016
    PROTAC YAP degrader-1

    		PROTACs YAP Cancer
    PROTAC YAP degrader-1 is a PROTAC that targets YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 consists of PROTAC target protein ligand NSC682769 (HY-168017) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019), where the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018) .
    PROTAC YAP degrader-1
  • HY-158342
    PROTAC TEAD degrader-1

    		PROTACs YAP Cancer
    PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain (TEAD). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC50 of 0.21 μM, and regulates expressions of yes associated protein (YAP) target genes. (Pink: TEAD ligand (HY-158400); Black: linker (HY-W008474); Blue: E3 ligase ligand (HY-W087383))
    PROTAC TEAD degrader-1
  • HY-168019
    (R,S,R)-AHPC-PEG2-C2-boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (R,S,R)-AHPC-PEG2-C2-boc is an E3 Ligase Ligand-Linker Conjugate. (R,S,R)-AHPC-PEG2-C2-boc can be used to synthesize PROTAC YAP degrader-1 (HY-168016) .
    (R,S,R)-AHPC-PEG2-C2-boc

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