PROTAC YAP degrader-1

Cat. No.: HY-168016 Purity: 99.77%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

PROTAC YAP degrader-1 (compound YZ-6) is a PROTAC targeting YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 is composed of PROTAC target protein ligand NSC682769 (HY-168017) (red part) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019) (blue+black part), in which the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018)^{[1]^.}

For research use only. We do not sell to patients.

PROTAC YAP degrader-1 Chemical Structure

CAS No. : 3058483-58-9

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

YAP^[1]

Molecular Weight

995.19

Formula

C₅₆H₆₂N₆O₉S

CAS No.

3058483-58-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCOCCOCCOC4=CC=C(C=C4OC)C5=C(C(C6=CC=CC=C6N7)=NC(C8=CC=CC=C8)=C5)CC7=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (100.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0048 mL	5.0242 mL	10.0483 mL
5 mM	0.2010 mL	1.0048 mL	2.0097 mL
10 mM	0.1005 mL	0.5024 mL	1.0048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) HNMR (373 KB) RP-HPLC (227 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0048 mL	5.0242 mL	10.0483 mL	25.1208 mL
	5 mM	0.2010 mL	1.0048 mL	2.0097 mL	5.0242 mL
	10 mM	0.1005 mL	0.5024 mL	1.0048 mL	2.5121 mL
	15 mM	0.0670 mL	0.3349 mL	0.6699 mL	1.6747 mL
	20 mM	0.0502 mL	0.2512 mL	0.5024 mL	1.2560 mL
	25 mM	0.0402 mL	0.2010 mL	0.4019 mL	1.0048 mL
	30 mM	0.0335 mL	0.1675 mL	0.3349 mL	0.8374 mL
	40 mM	0.0251 mL	0.1256 mL	0.2512 mL	0.6280 mL
	50 mM	0.0201 mL	0.1005 mL	0.2010 mL	0.5024 mL
	60 mM	0.0167 mL	0.0837 mL	0.1675 mL	0.4187 mL
	80 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3140 mL
	100 mM	0.0100 mL	0.0502 mL	0.1005 mL	0.2512 mL