2. PROTAC Stem Cell/Wnt
  3. YAP PROTACs
  4. PROTAC YAP degrader-1

PROTAC YAP degrader-1 is a PROTAC that targets YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 consists of PROTAC target protein ligand NSC682769 (HY-168017) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019), where the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018).

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PROTAC YAP degrader-1 Chemical Structure

PROTAC YAP degrader-1 Chemical Structure

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PROTAC YAP degrader-1 Related Antibodies

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Description

PROTAC YAP degrader-1 is a PROTAC that targets YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 consists of PROTAC target protein ligand NSC682769 (HY-168017) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019), where the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018)[1].

IC50 & Target

YAP[1]
Molecular Weight

995.19

Formula

C56H62N6O9S
SMILES

O=C(N[C@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@@H]3N(C[C@H](C3)O)C([C@@H](C(C)(C)C)NC(CCOCCOCCOC4=CC=C(C=C4OC)C5=C(C(C6=CC=CC=C6N7)=NC(C8=CC=CC=C8)=C5)CC7=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC YAP degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC YAP degrader-1PROTAC YAP degrader1PROTAC YAP degrader 1YAPPROTACsYes-associated proteinInhibitorinhibitorinhibit

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