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PTPN2/1-IN-2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153638
    PTPN2/1-IN-2

    		Phosphatase Cancer
    PTPN2/1-IN-2 is a PTPN2/1 antagonist that can be used in various tumor research .
    PTPN2/1-IN-2
  • HY-149760
    PVD-06

    		PROTACs Phosphatase Cancer
    PVD-06 is a selective PROTAC-class PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) with anticancer activity. PVD-06 induces PTPN2 degradation via ubiquitination and proteasome-dependent pathways. PVD-06 can promote T cell activation and amplify IFN-γ-mediated cytotoxicity . PVD-06 consists of a target protein ligand (red part) PTPN2 ligand 1 (HY-168691), a PROTAC linker (black part) 6-Aminocaproic acid (HY-B0236), and an E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC-Me (HY-112078). E3 ubiquitin ligase+linker can form 6-Aminocaproic acid-(S,R,S)-AHPC-Me (HY-168690).
    PVD-06
  • HY-156607
    Anticancer agent 143

    		Phosphatase Cancer
    Anticancer agent 143 (compound 369) is a dual PTPN2/PTP1B inhibitor with IC50 values <2.5 nM. Anticancer agent 143 can be used in cancer research .
    Anticancer agent 143
  • HY-156608
    Anticancer agent 144

    		Phosphatase Cancer
    Anticancer agent 144 (compound 444) is a dual PTPN2/PTP1B inhibitor with IC50 values <2.5 nM. Anticancer agent 144 can be used in cancer research .
    Anticancer agent 144

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