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Results for "

RAP 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) Farnesyl Transferase (2) Integrin (1) Ras (7) Small Interfering RNA (siRNA) (6)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (6) siRNAs (6)

Inhibitors & Agonists

Peptides

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126133

AM-001	Ras	Cardiovascular Disease Others
AM-001 is a non-competitive inhibitor of Epac1 that blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells. AM-001 can be used in heart disease-related research .

HY-117958

HJC0197 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

HY-169295

*RAP 1*	Biochemical Assay Reagents	Others
RAP 1 is a reactive affinity probe (RAP) that selectively labels SLC6A8 in the presence of guanine alanine (GPA). RAP 1 can be used as a chemical probe for identifying and studying potential drug binding sites on SLC6A8 .

HY-RS11652

RAP1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1A Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1A Human Pre-designed siRNA Set A RAP1A Human Pre-designed siRNA Set A

HY-RS11653

RAP1B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1B Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1B Human Pre-designed siRNA Set A RAP1B Human Pre-designed siRNA Set A

HY-RS11654

RAP1GAP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1GAP Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP Human Pre-designed siRNA Set A RAP1GAP Human Pre-designed siRNA Set A

HY-RS11655

RAP1GAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1GAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP2 Human Pre-designed siRNA Set A RAP1GAP2 Human Pre-designed siRNA Set A

HY-RS11656

RAP1GDS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1GDS1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GDS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GDS1 Human Pre-designed siRNA Set A RAP1GDS1 Human Pre-designed siRNA Set A

HY-RS02389

CDK5RAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDK5RAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5RAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK5RAP1 Human Pre-designed siRNA Set A CDK5RAP1 Human Pre-designed siRNA Set A

HY-116312

8-CPT-2'-O-Me-cAMP	Ras	Cardiovascular Disease
8-CPT-2'-O-Me-cAMP is a *Rap1* activator. 8-CPT-2'-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .

HY-P10038

mP6 Myr-FEEERA-OH	Integrin	Infection
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα₁₃ with integrin β₃ without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .

HY-107543

8-CPT-2Me-cAMP sodium	Ras	Others
8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀> 10 μM) . 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca ²⁺ release in pancreatic β-cells in vitro .

HY-12369

GGTI-2133	Others	Inflammation/Immunology
GGTI-2133 is an inhibitor for geranylgeranyltransferase I (GGTase-I) with an IC₅₀ of 38 nM. GGTI-2133 inhibits the geranylation of *Rap-1A* with an IC₅₀ of 10 μM .

HY-12369A

GGTI-2133 TFA	Others	Inflammation/Immunology
GGTI-2133 TFA is the TFA salt form of GGTI-2133 (HY-12369). GGTI-2133 TFA is an inhibitor for geranylgeranyltransferase I (GGTase-I) with an IC₅₀ of 38 nM. GGTI-2133 TFA inhibits the geranylation of *Rap-1A* with an IC₅₀ of 10 μM .

HY-132276

PtdIns-(3,4,5)-P3-biotin sodium	Others	Others
PtdIns-(3,4,5)-P3-biotin sodium is a Biotin-labeled PtdIns-(3,4,5)-P3 (PI(3,4,5)P3). PI(3,4,5)P3 is a substrate of nuclear phosphatidylinositol 5-phosphatase (PIP5Pase). PI(3,4,5)P3 binds to the N-terminus of *RAP1* (repressor activator protein 1) and controls its DNA binding activity .

HY-15871

GGTI298 Trifluoroacetate 3 Publications Verification	Apoptosis	Cancer
GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit *Rap1A* with IC₅₀ of 3 μM; little effect on Ha-Ras with IC₅₀ of >20 μM.

HY-100876

GGTI298	Apoptosis	Cancer
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC₅₀ values of 3 and > 20 μM in vivo, respectively.

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-123242A

FTI-2153 TFA	Farnesyl Transferase	Cancer
FTI-2153 TFA is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 TFA is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-120271

GGTI-297	Ras	Cancer
GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC₅₀ values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras .

HY-120229

GGTI-2147	Others	Neurological Disease
GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia .

HY-117935

GGTI-286 hydrochloride	Ras	Cancer
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM .

HY-115489

GGTI-286	Ras	Cancer
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM .

HY-115489A

GGTI-286 TFA	Others	Cancer
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM .

Cat. No.	Product Name	Target	Research Area

HY-P10038

mP6 Myr-FEEERA-OH	Integrin	Infection
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα₁₃ with integrin β₃ without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82079

	RAP1 Antibody (YA1824) Ras-related protein RAP-1b; K-REV; RAL1B	WB, IP	Human, Mouse, Rat
	RAP1 Antibody (YA1824) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1824), targeting RAP1, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). RAP1 Antibody (YA1824) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82081

	RAP1GAP Antibody (YA1826) RAP1GAP; KIAA0474; RAP1GA1; RAP1 GTPase-activating protein 1; RAP1GAP; RAP1GAP1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RAP1GAP Antibody (YA1826) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1826), targeting RAP1GAP, with a predicted molecular weight of 73 kDa (observed band size: 95 kDa). RAP1GAP Antibody (YA1826) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82893

	D4 GDI Antibody (YA2638) Rho GDP dissociation inhibitor (GDI) beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2	WB, IHC-F, IHC-P, ICC/IF	Human
	D4 GDI Antibody (YA2638) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2638), targeting D4 GDI, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). D4 GDI Antibody (YA2638) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

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RAP1A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAP1A Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1B Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAP1B Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAP1GAP Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAP1GAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GDS1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAP1GDS1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GDS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK5RAP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CDK5RAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5RAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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