GGTI-286 TFA

Cat. No.: HY-115489A: FAQs
Data Sheet Handling Instructions

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GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM.

For research use only. We do not sell to patients.

GGTI-286 TFA Chemical Structure

Size	Price	Stock
1 mg	USD 360	Ask For Quote & Lead Time
5 mg	USD 920	Ask For Quote & Lead Time
10 mg	USD 1500	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of GGTI-286 TFA:

GGTI-286 Get quote
GGTI-286 hydrochloride Get quote

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Description

In Vitro

GGTI-286 (10 μM; 2 and 4 h; CHO cells) TFA reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	CHO cells
Concentration:	10 μM
Incubation Time:	2 and 4 h
Result:	Reduced the nuclear b-catenin amount.

Molecular Weight

543.60

Formula

C₂₅H₃₂F₃N₃O₅S

SMILES

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [Content Brief]

[2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540. [Content Brief]

GGTI-286 TFA Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGTI-286GGTI286GGTI 286OthersNIH3T3CHOcell-permeableK-Ras4BgeranylgeranylationInhibitorinhibitorinhibit

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