2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. 8-CPT-2'-O-Me-cAMP

8-CPT-2'-O-Me-cAMP is a Rap1 activator. 8-CPT-2'-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration.

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8-CPT-2'-O-Me-cAMP Chemical Structure

8-CPT-2'-O-Me-cAMP Chemical Structure

CAS No. : 510774-50-2

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8-CPT-2'-O-Me-cAMP Related Antibodies

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Description

8-CPT-2'-O-Me-cAMP is a Rap1 activator. 8-CPT-2'-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration[1].

IC50 & Target

Rap1[1]
In Vitro

8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances recruitment of junctional proteins and cortical F-actin in retinal pigment epithelium cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8-CPT-2'-O-Me-cAMP Related Antibodies
In Vivo

8-CPT-2'-O-Me-cAMP (2.05µM; 1 µL; intravitreal injection) inhibits development of choroidal neovascular lesions in a laser-injury model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type (WT) C57/Bl6 mice (choroidal neovascularization (CNV) model) [1]
Dosage: 2.05µM; 1 µL
Administration: Intravitreal injection
Result: Induced a slight increase in F-actin localization to the cell periphery, and reorganized cell junctions to a more linear shape, dose-dependent decreased in CNV volume, increased Rap1 activity in isolated RPE/choroids.
Molecular Weight

485.84

Formula

C17H17ClN5O6PS
CAS No.
SMILES

NC1=C2C(N([C@H]3[C@@H]([C@@]4([H])[C@](COP(O)(O4)=O)([H])O3)OC)C(SC5=CC=C(C=C5)Cl)=N2)=NC=N1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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8-CPT-2'-O-Me-cAMP Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-CPT-2'-O-Me-cAMP510774-50-2Rasretinal pigment epithelium barrierF-actinchoroidal neovascularizationInhibitorinhibitorinhibit

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