GGTI-286

Cat. No.: HY-115489: FAQs
Data Sheet Handling Instructions

Molarity Calculator

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM.

For research use only. We do not sell to patients.

GGTI-286 Chemical Structure

CAS No. : 171744-11-9

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of GGTI-286:

GGTI-286 TFA Get quote
GGTI-286 hydrochloride Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Ras Isoform Specific Products:

View All Isoforms

K-Ras H-Ras N-Ras Ras

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 2 μM (Geranylgeranylation of Rap1A) in NIH3T3 cells^[1]

In Vitro

GGTI-286 (10 μM; 2 and 4 h; CHO cells) reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	CHO cells
Concentration:	10 μM
Incubation Time:	2 and 4 h
Result:	Reduced the nuclear b-catenin amount.

Molecular Weight

429.58

Formula

C₂₃H₃₁N₃O₃S

CAS No.

171744-11-9

SMILES

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (116.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3279 mL	11.6393 mL	23.2786 mL
5 mM	0.4656 mL	2.3279 mL	4.6557 mL
10 mM	0.2328 mL	1.1639 mL	2.3279 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [Content Brief]

[2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3279 mL	11.6393 mL	23.2786 mL	58.1964 mL
	5 mM	0.4656 mL	2.3279 mL	4.6557 mL	11.6393 mL
	10 mM	0.2328 mL	1.1639 mL	2.3279 mL	5.8196 mL
	15 mM	0.1552 mL	0.7760 mL	1.5519 mL	3.8798 mL
	20 mM	0.1164 mL	0.5820 mL	1.1639 mL	2.9098 mL
	25 mM	0.0931 mL	0.4656 mL	0.9311 mL	2.3279 mL
	30 mM	0.0776 mL	0.3880 mL	0.7760 mL	1.9399 mL
	40 mM	0.0582 mL	0.2910 mL	0.5820 mL	1.4549 mL
	50 mM	0.0466 mL	0.2328 mL	0.4656 mL	1.1639 mL
	60 mM	0.0388 mL	0.1940 mL	0.3880 mL	0.9699 mL
	80 mM	0.0291 mL	0.1455 mL	0.2910 mL	0.7275 mL
	100 mM	0.0233 mL	0.1164 mL	0.2328 mL	0.5820 mL

GGTI-286 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGTI-286171744-11-9GGTI286GGTI 286RasNIH3T3CHOcell-permeableK-Ras4BgeranylgeranylationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks