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Results for "

Runx-2

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

7

Natural
Products

2

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107999
    CADD522
    3 Publications Verification

    		 Reactive Oxygen Species Cancer
    CADD522 is a RUNX2-DNA binding inhibitor (downregulates RUNX2-mediated transcription of downstream target genes), with an IC50 of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer [2].
    CADD522
  • HY-127090
    Muramyl dipeptide
    3 Publications Verification

    MDP

    		 p38 MAPK NOD-like Receptor (NLR) Inflammation/Immunology Cancer
    Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist [2].
    Muramyl dipeptide
  • HY-N2375
    L-Quebrachitol

    		Wnt β-catenin p38 MAPK Metabolic Disease
    L-Quebrachitol is a methoxy analog of inositol isolated from plants, which has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway [2] .
    L-Quebrachitol
  • HY-103701
    L-Ascorbic acid 2-phosphate
    1 Publications Verification

    2-Phospho-L-ascorbic acid

    		 Phosphatase Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation [2] .
    L-Ascorbic acid 2-phosphate
  • HY-103701B
    L-Ascorbic acid 2-phosphate magnesium hydrate
    1 Publications Verification

    2-Phospho-L-ascorbic acid magnesium hydrate

    		 Phosphatase Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation [2] .
    L-Ascorbic acid 2-phosphate magnesium hydrate
  • HY-133108
    Azadirachtin B

    		EBV Parasite Phosphatase Influenza Virus Infection Metabolic Disease Inflammation/Immunology Cancer
    Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties [2] .
    Azadirachtin B
  • HY-107837
    L-Ascorbic acid 2-phosphate trisodium
    1 Publications Verification

    2-Phospho-L-ascorbic acid trisodium

    		 Phosphatase Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation [2] .
    L-Ascorbic acid 2-phosphate trisodium
  • HY-RS12351
    RUNX2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RUNX2 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RUNX2 Human Pre-designed siRNA Set A
    RUNX2 Human Pre-designed siRNA Set A
  • HY-N0946
    (-)-Pinoresinol 4-O-glucoside

    (-)-Pinoresinol 4-O-β-D-glucopyranoside

    		 Glucosidase Metabolic Disease
    (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease [2].
    (-)-Pinoresinol 4-O-glucoside
  • HY-145896
    Anti-osteoporosis agent-1

    		Apoptosis Inflammation/Immunology
    Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC50=18 µM) .
    Anti-osteoporosis agent-1
  • HY-103701A
    L-Ascorbic acid 2-phosphate magnesium
    1 Publications Verification

    2-Phospho-L-ascorbic acid magnesium

    		 Phosphatase Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation [2] .
    L-Ascorbic acid 2-phosphate magnesium

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