2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Phosphatase Reactive Oxygen Species Endogenous Metabolite
  4. L-Ascorbic acid 2-phosphate

L-Ascorbic acid 2-phosphate  (Synonyms: 2-Phospho-L-ascorbic acid)

Cat. No.: HY-103701 Assay: 37.4%
SDS COA Handling Instructions

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L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate Chemical Structure

L-Ascorbic acid 2-phosphate Chemical Structure

CAS No. : 23313-12-4

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Based on 2 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid 2-phosphate:

L-Ascorbic acid 2-phosphate Related Antibodies

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2 Publications Citing Use of MCE L-Ascorbic acid 2-phosphate

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Description

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc)  achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid 2-phosphate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human corneal endothelial cells (HCECs) 
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
Molecular Weight

256.10

Formula

C6H9O9P
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

OC([C@H](O1)[C@H](CO)O)=C(OP(O)(O)=O)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

1 M HCL : 25 mg/mL (97.62 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9047 mL 19.5236 mL 39.0472 mL
5 mM 0.7809 mL 3.9047 mL 7.8094 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 37.4%

SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1 M HCL 1 mM 3.9047 mL 19.5236 mL 39.0472 mL 97.6181 mL
5 mM 0.7809 mL 3.9047 mL 7.8094 mL 19.5236 mL
10 mM 0.3905 mL 1.9524 mL 3.9047 mL 9.7618 mL
15 mM 0.2603 mL 1.3016 mL 2.6031 mL 6.5079 mL
20 mM 0.1952 mL 0.9762 mL 1.9524 mL 4.8809 mL
25 mM 0.1562 mL 0.7809 mL 1.5619 mL 3.9047 mL
30 mM 0.1302 mL 0.6508 mL 1.3016 mL 3.2539 mL
40 mM 0.0976 mL 0.4881 mL 0.9762 mL 2.4405 mL
50 mM 0.0781 mL 0.3905 mL 0.7809 mL 1.9524 mL
60 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6270 mL
80 mM 0.0488 mL 0.2440 mL 0.4881 mL 1.2202 mL
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L-Ascorbic acid 2-phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid 2-phosphate23313-12-42-Phospho-L-ascorbic acidPhosphataseReactive Oxygen SpeciesEndogenous MetabolitehASCosteogenicdifferentiationmediumsupplementrunx2AvitaminCderivativeInhibitorinhibitorinhibit

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