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Isoforms Recommended:	USP2

Results for "

USP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (3) Deubiquitinase (14) DNA Methyltransferase (2) Endogenous Metabolite (2) SARS-CoV (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (13) Infection (4) Inflammation/Immunology (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149229

USP28-IN-3	Deubiquitinase	Cancer
USP28-IN-3 is a *USP28* inhibitor (IC₅₀=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-149230

USP28-IN-4	Deubiquitinase	Cancer
USP28-IN-4 is a *USP28* inhibitor (IC₅₀=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-13765

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits *USP2* activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-100900

ML364 10+ Cited Publications	Deubiquitinase	Cancer
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC₅₀=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (K_d=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP ^[2].

HY-100708

NSC632839 3 Publications Verification	Deubiquitinase	Cancer
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits *USP2, USP7, and SENP2* with EC₅₀s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.

HY-RS15530

USP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Deubiquitinase	Others
USP2 Human Pre-designed siRNA Set A contains three designed siRNAs for USP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

USP2 Human Pre-designed siRNA Set A USP2 Human Pre-designed siRNA Set A

HY-149228

USP28-IN-2	Deubiquitinase	Cancer
USP28-IN-2 is a *USP28* inhibitor (IC₅₀=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-162312

LLK203	Deubiquitinase Apoptosis	Cancer
LLK203 is a potent *USP2/USP8* dual-target inhibitor with IC₅₀s of 0.89 μM and 0.52 μM, respectively. LLK203 leads a degradation of ERα and induces apoptosis of breast cancer MCF-7 cells. LLK203 demonstrates antitumor activities against the 4T1 tumor mice model .

HY-13765R

6-Thioguanine (Standard)	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits *USP2* activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-168266

MS1172 XH161-172	Deubiquitinase	Infection Cancer
MS1172 (XH161-172; Example 54) is an orally active and potent inhibitor of *USP2*. MS1172 plays an important role in cancer and virus infection .

HY-13814

PR-619 Maximum Cited Publications 17 Publications Verification	Deubiquitinase Autophagy Apoptosis	Cancer
PR-619 is a broad-range and reversible DUB inhibitor with EC₅₀s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for *USP4, USP8, USP7, USP2, and USP5*, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis ^[2] .

HY-168267

XH161-180	Deubiquitinase	Infection Cancer
XH161-180 is a potent and orally active ubiquitin carboxyl-terminal hydrolase 2 (USP2) inhibitor. XH161-180 decreases the protein of cyclin D and ACE2. XH161-180 shows antiproliferative activity. XH161-180 has the potential for the research of cancer and virus infection depending on ACE2 .

HY-120458

LCAHA 1 Publications Verification LCA hydroxyamide	Deubiquitinase	Cancer
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC₅₀s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .

HY-124855

STD1T 1 Publications Verification	Deubiquitinase	Cancer
STD1T is a deubiquitinase USP2a inhibitor with an IC₅₀ of 3.3 μM in Ub-AMC Assay .

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits *USP2* activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

6-Thioguanine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits *USP2* activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701349

	USP2 Protein, Human USP2; Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free. The total length of USP2 Protein, Human is 347 a.a., .

HY-P79457

	USP2 Catalytic Domain Protein, Human (His) Ubiquitin Specific Peptidase 2; UBP41; Ubiquitin-Specific-Processing Protease 2; Ubiquitin Carboxyl-Terminal Hydrolase 2; 41 KDa Ubiquitin-Specific Protease; Deubiquitinating Enzyme 2; Ubiquitin-specific Protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Catalytic Domain Protein, Human (His) is the recombinant human-derived USP2 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

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USP2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
USP2 Human Pre-designed siRNA Set A contains three designed siRNAs for USP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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