Search Result
Results for "
anti-tussive
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-148144A
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- HY-N0829
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Others
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Inflammation/Immunology
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Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .
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- HY-135976
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P2X Receptor
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Neurological Disease
Inflammation/Immunology
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P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect .
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- HY-136026
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BLU-5937
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P2X Receptor
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Inflammation/Immunology
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Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough .
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- HY-148144
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- HY-101828
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- HY-B2215
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- HY-N3163
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- HY-B0505
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- HY-106372A
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- HY-N1471
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- HY-N8197
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Others
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Cancer
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Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound .
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- HY-106495
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- HY-B2115
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- HY-N0413
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Others
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Inflammation/Immunology
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Hupehenine, a bioactive isosteroidal alkaloid, is a main antitussive components present in most of Fritillaria hupehensis .
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- HY-121644
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- HY-106873
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Others
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Others
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Nepinalone, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
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- HY-106873A
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Others
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Others
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Nepinalone hydrochloride, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
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- HY-N7600
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25-Epieduardine; Puqiedinone
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Others
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Others
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Zhebeirine (Puqiedinone), a steroidal alkaloid, is isolated from the bulbs of Fritillaria puqiensis. Zhebeirine exhibits antitussive and expectorant properties .
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- HY-B1032
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(±)-Dropropizine; UCB-196
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Others
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Neurological Disease
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Dropropizine ((±)-Dropropizine) is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
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- HY-B1895
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- HY-N3196
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Bacterial
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Infection
Inflammation/Immunology
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Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages .
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- HY-B2090
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SKF 70230A; SQ 15874; Pipazetate
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GABA Receptor
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Others
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Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant .
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- HY-N10620
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Others
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Inflammation/Immunology
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Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .
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- HY-A0161
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Clofedanol; Calmotusin; NSC 113595
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Others
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Infection
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Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
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- HY-A0161A
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Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride
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Others
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Infection
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Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
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- HY-B1895S
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- HY-13716S
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Isotope-Labeled Compounds
Apoptosis
Opioid Receptor
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Cancer
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-W354753
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mAChR
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Others
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Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .
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- HY-N0808
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Camphor
1 Publications Verification
(±)-Camphor
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TRP Channel
Influenza Virus
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Infection
Inflammation/Immunology
Cancer
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Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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- HY-121388
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(+)-Ledol
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Fungal
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Infection
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Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting .
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- HY-B1038
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Others
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Inflammation/Immunology
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L-Cysteine methyl ester hydrochloride is an antitussive, phlegmolytic agent used to relieve breathing difficulties caused by large amounts of phlegm. L-Cysteine methyl ester hydrochloride is a copper corrosion inhibitor used in various industrial studies .
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- HY-B1551
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Benzononatine
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Sodium Channel
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Neurological Disease
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Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite .
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- HY-B1032R
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(±)-Dropropizine (Standard); UCB-196 (Standard)
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Others
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Neurological Disease
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Dropropizine (Standard) is the analytical standard of Dropropizine. This product is intended for research and analytical applications. Dropropizine ((±)-Dropropizine) is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
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- HY-B1895R
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Histamine Receptor
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Neurological Disease
Inflammation/Immunology
Endocrinology
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Levodropropizine (Standard) is the analytical standard of Levodropropizine. This product is intended for research and analytical applications. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .
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- HY-N3197
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(+)-Neostenine
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P-glycoprotein
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Cancer
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Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .
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- HY-N1377
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Bacterial
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Infection
Metabolic Disease
Inflammation/Immunology
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Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .
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- HY-B2078A
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Neurokinin Receptor
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Inflammation/Immunology
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Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .
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- HY-N10824
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Others
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Others
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2,3,5,6-Tetramethoxyaporphine is an antitussive agent, a medicinally valuable benzyl isoquinoline alkaloid. 2,3,5,6-Tetramethoxyaporphine can be isolated from the yellow hornpoppy, Glaucium flavum Cr. (Fam. Papaveraceae) .
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- HY-121685A
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Potassium Channel
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Neurological Disease
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Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron . Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .
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- HY-121685
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Potassium Channel
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Neurological Disease
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Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .
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- HY-A0161S
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Clofedanol-13C6; Calmotusin-13C6; NSC 113595-13C6
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Isotope-Labeled Compounds
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Infection
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
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- HY-N0808R
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TRP Channel
Influenza Virus
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Infection
Inflammation/Immunology
Cancer
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Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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- HY-103212A
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B-HT 933 hydrochloride; Oxazoloazepin hydrochloride
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Adrenergic Receptor
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Cardiovascular Disease
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Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy .
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- HY-N3945
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O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396
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Phosphodiesterase (PDE)
Calcium Channel
Adrenergic Receptor
Dopamine Receptor
Influenza Virus
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Infection
Inflammation/Immunology
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Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca 2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .
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- HY-134004
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Carbetapentane
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Sigma Receptor
mAChR
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Neurological Disease
Inflammation/Immunology
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Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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- HY-B1055
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Carbetapentane citrate
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Sigma Receptor
mAChR
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Neurological Disease
Inflammation/Immunology
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Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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- HY-134004R
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Sigma Receptor
mAChR
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Neurological Disease
Inflammation/Immunology
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Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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Cat. No. |
Product Name |
Type |
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- HY-W354753
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Biochemical Assay Reagents
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Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1895S
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Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
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- HY-13716S
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-A0161S
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
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