Sulfogaiacol

Cat. No.: HY-B2115 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sulfogaiacol is a cough suppressant with expectorant properties, and it can be used for research on acute respiratory infections with oral activity.

For research use only. We do not sell to patients.

Sulfogaiacol Chemical Structure

CAS No. : 1321-14-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sulfogaiacol is a cough suppressant with expectorant properties, and it can be used for research on acute respiratory infections with oral activity^[1]^[2].

In Vivo

Sulfogaiacol (100 mg/kg, daily, 3 days) has a mucolytic effect in Swiss albino strains mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	White male mice with Swiss albino strains^[2]
Dosage:	100 mg/kg, daily, 3 days
Administration:	Oral
Result:	Diluted respiratory mucosal secretions and had a expectorant effect.

Molecular Weight

242.29

Formula

C₇H₇O₅S.K

CAS No.

1321-14-8

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1OC.O=S(C)(O[K])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (206.36 mM)

DMSO : 50 mg/mL (206.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1273 mL	20.6364 mL	41.2729 mL
5 mM	0.8255 mL	4.1273 mL	8.2546 mL
10 mM	0.4127 mL	2.0636 mL	4.1273 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (206.36 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (256 KB) RP-HPLC (230 KB)

Handling Instructions (2659 KB)

References

[1]. Armand C, et al. [Neocodion misuse: evolution between 1992 and 2002]. Therapie. 2004 Sep-Oct;59(5):547-53. [Content Brief]

[2]. NGUYEN DUY TAN, et al. INVESTIGATION OF TOXICITY, ANTIMICROBIAL ACTIVITY AND COUGH TREATMENT OF PRODUCTS PRODUCED FROM Pouzolzia zeylanica PLANTS GROWING IN VIETNAM. Malays. Appl. Biol. (2020) 49(3): 43–51.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.1273 mL	20.6364 mL	41.2729 mL	103.1821 mL
	5 mM	0.8255 mL	4.1273 mL	8.2546 mL	20.6364 mL
	10 mM	0.4127 mL	2.0636 mL	4.1273 mL	10.3182 mL
	15 mM	0.2752 mL	1.3758 mL	2.7515 mL	6.8788 mL
	20 mM	0.2064 mL	1.0318 mL	2.0636 mL	5.1591 mL
	25 mM	0.1651 mL	0.8255 mL	1.6509 mL	4.1273 mL
	30 mM	0.1376 mL	0.6879 mL	1.3758 mL	3.4394 mL
	40 mM	0.1032 mL	0.5159 mL	1.0318 mL	2.5796 mL
	50 mM	0.0825 mL	0.4127 mL	0.8255 mL	2.0636 mL
	60 mM	0.0688 mL	0.3439 mL	0.6879 mL	1.7197 mL
	80 mM	0.0516 mL	0.2580 mL	0.5159 mL	1.2898 mL
	100 mM	0.0413 mL	0.2064 mL	0.4127 mL	1.0318 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sulfogaiacol Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfogaiacol1321-14-8BacterialCough reliefexpectorantInhibitorinhibitorinhibit

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