2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tipepidine

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.

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Tipepidine Chemical Structure

Tipepidine Chemical Structure

CAS No. : 5169-78-8

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Tipepidine Related Antibodies

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Description

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

IC50 & Target

IC50: 7.0 μM (dopamine D2 receptor)[1]
In Vivo

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2]
Dosage: 10, 20 and 40 mg/kg.
Administration: I.p.; 0.5, 5, 23 hours.
Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Clinical Trial
Molecular Weight

275.43

Formula

C15H17NS2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (907.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6307 mL 18.1534 mL 36.3069 mL
5 mM 0.7261 mL 3.6307 mL 7.2614 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6307 mL 18.1534 mL 36.3069 mL 90.7672 mL
5 mM 0.7261 mL 3.6307 mL 7.2614 mL 18.1534 mL
10 mM 0.3631 mL 1.8153 mL 3.6307 mL 9.0767 mL
15 mM 0.2420 mL 1.2102 mL 2.4205 mL 6.0511 mL
20 mM 0.1815 mL 0.9077 mL 1.8153 mL 4.5384 mL
25 mM 0.1452 mL 0.7261 mL 1.4523 mL 3.6307 mL
30 mM 0.1210 mL 0.6051 mL 1.2102 mL 3.0256 mL
40 mM 0.0908 mL 0.4538 mL 0.9077 mL 2.2692 mL
50 mM 0.0726 mL 0.3631 mL 0.7261 mL 1.8153 mL
60 mM 0.0605 mL 0.3026 mL 0.6051 mL 1.5128 mL
80 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1346 mL
100 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9077 mL
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Tipepidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tipepidine5169-78-8Potassium ChannelKcsAantidepressant-likenon-narcotic antitussivedopamineGIRKInhibitorinhibitorinhibit

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