Chlophedianol (Synonyms: Clofedanol; Calmotusin; NSC 113595)

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Data Sheet Handling Instructions

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Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs).

For research use only. We do not sell to patients.

Chlophedianol Chemical Structure

CAS No. : 791-35-5

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Other Forms of Chlophedianol:

Chlophedianol-¹³C₆ Get quote
Chlophedianol hydrochloride Get quote

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Description

Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)^[1]^[2].

In Vivo

Chlophedianol hydrochloride (0-162 mg/kg; p.o. or s.c.; once) lowers the volume output of respiratory tract fluid in rabbits and cats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Healthy, adult, male rabbits and cats^[1]
Dosage:	2.0, 6.0, 18, 54 and 162 mg/kg (PO) or 1.0, 3.0, 9.0, 27 and 81 mg/kg (SC)
Administration:	Oral or subcutaneous administration, once
Result:	Lowered the volume output of respiratory tract fluid, slightly but significantly over a period of one to three hours after administration. Produced a decrease in the number of animals in which pledgets of mucus appeared in the respiratory tract.

Molecular Weight

289.80

Formula

C₁₇H₂₀ClNO

CAS No.

791-35-5

SMILES

OC(C1=CC=CC=C1)(CCN(C)C)C2=CC=CC=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Boyd EM, et al. Chlophedianol Hydrochloride: A New Antitussive Agent. Can Med Assoc J. 1960 Dec 17;83(25):1298-301. [Content Brief]

[2]. Paul IM. Therapeutic options for acute cough due to upper respiratory infections in children. Lung. 2012 Feb;190(1):41-4. [Content Brief]

Chlophedianol Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlophedianol791-35-5Clofedanol Calmotusin NSC 113595NSC113595NSC 113595NSC-113595Otherscoughantitussiveupper respiratory tract infectionsInhibitorinhibitorinhibit

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