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antifungal metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (1) Endogenous Metabolite (9) Antibiotic (4) Apoptosis (4) Bacterial (10) Fungal (23) HIV (1) Lipase (1) Lipoxygenase (1) Parasite (2) Wnt (2)
By Research Areas:	Cancer (5) Infection (34) Inflammation/Immunology (5) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121362

Evernic Acid	Bacterial Endogenous Metabolite	Inflammation/Immunology
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-113219

Hydroxyphenyllactic acid 1 Publications Verification	Endogenous Metabolite Fungal	Infection
Hydroxyphenyllactic acid is an *antifungal* metabolite.

HY-12772

Hydroxy Itraconazole Itraconazole metabolite Hydroxy Itraconazole; R-63373	Fungal Drug Metabolite	Others
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole *antifungal* agent.

HY-N10215

Canadensolide	Fungal Endogenous Metabolite	Infection
Canadensolide is an antifungal metabolite of Penicillium canadense.

HY-124551

Viridiol	Fungal Antibiotic	Infection
Viridiol, a fungal metabolite from Trichodernza viride, shows antifungal activity .

HY-N10288

Eucalyptacid A	Fungal Endogenous Metabolite	Infection
Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM .

HY-N8499

Sporothriolide	Fungal	Infection
Sporothriolide is a metabolite produced by Nodulisporium sp. A21. Sporothriolide has potently antifungal against R. solani and S. sclerotiorum, with EC₅₀ values of 11.6 μM and 10.7 μM, respectively. Sporothriolide inhibits conidium germination of Magnaporthe oryzae in vitro and in vivo .

HY-N10289

Cytosporone C	Fungal	Infection
Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani .

HY-167831

Vermistatin	Fungal	Infection
Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity .

HY-125723

Echinocandin B SL 7810; A-30912 A	Endogenous Metabolite Fungal Antibiotic	Infection
Echinocandin B (A 30912) is an antifungal antibiotic and is the secondary metabolite produced by Aspergillus nidulans .

HY-I0903

SCH 51048	Others	Others
SCH 51048 is a compound that can produce active metabolites, and its active metabolites have antifungal activity. Through metabolic studies and activity screening of the compound, metabolites and compounds with better activity were discovered.

HY-113219R

Hydroxyphenyllactic acid (Standard)	Endogenous Metabolite Fungal	Infection
Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.

HY-W741557

Griseofulvic Acid (±)-Griseofulvic acid	Others	Infection
Griseofulvic acid is a metabolite of the antifungal Griseofulvin (HY-17583). It induces protein aggregation and tubulin polymerization in cell-free assays.

HY-165017

Etheroleic acid	Fungal	Infection
Etheroleic acid has antifungal activity against the powdery mildew B. graminis on the second leaves of barley seedlings. Etheroleic acid is a metabolite of Linolenic acid .

HY-12772S

Hydroxy Itraconazole-d8 R-63373-d₈	Fungal	Others
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-118118

Phlebiakauranol aldehyde	Others	Infection
Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite with strong antifungal activity. Phlebiakauranol aldehyde exhibits significant antibacterial and cytotoxic activities against a variety of plant pathogens. The aldehyde group and high number of hydroxyl groups of Phlebiakauranol aldehyde are considered to be the main reasons for its biological activity. The two acetic acid derivatives of Phlebiakauranol aldehyde only exhibit very weak antifungal and antibacterial activities and moderate cytotoxic activity .

HY-N12893

Sclerodione	Fungal Lipase	Infection
Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC₅₀: 1 μM) .

HY-N12260

Benanomicin A	HIV Bacterial	Infection
Benanomicin A is a microbial metabolite and can be isolated from Actinomycetes.Benanomicin has antifungal activitya and inhibits HIV-1 viral infection in MT-4 cells .

HY-129315

Deacylketoconazole N-Deacetylketoconazole; R-39519	Bacterial Fungal	Infection
Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte .

HY-100711

Prodigiosin 1 Publications Verification Prodigiosine; NSC47147	Bacterial Apoptosis Wnt Fungal Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N11528

Eugenitol 7-Noreugenitin	Others	Infection
Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .

HY-N10292

Chaetosemin J	Fungal Endogenous Metabolite	Infection
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .

HY-122785

Fusapyrone	Others	Infection
Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.

HY-100711A

Prodigiosin hydrochloride 1 Publications Verification Prodigiosine hydrochloride	Bacterial Apoptosis Fungal Wnt Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-125706

1233B	Fungal Antibiotic	Infection
1233B is a secondary metabolite from filamentous fungus, Fusarium sp. RK97-94 .

HY-17011

Croconazole	Others	Metabolic Disease
Croconazole is an *antifungal* agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .

HY-121178

Deoxyviolacein	Others	Infection
Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.

HY-W014589

2,4-Di-tert-butylphenol 1 Publications Verification 2,4-DTBP	Endogenous Metabolite Fungal Apoptosis	Infection Inflammation/Immunology Cancer
2,4-Di-tert-butylphenol (2,4-DTBP) is an endogenous metabolite with anti-inflammatory and antioxidant activities and induces the expression of apoptosis genes in cancer cell lines. 2,4-Di-tert-butylphenol also exhibits antiviral and antifungal activities .

HY-N6780

Ophiobolin B	Fungal	Infection
Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement . The MIC values with the *antifungal* effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL .

HY-N6027

Cyclosporin C	Fungal Bacterial	Infection
Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including *antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium* species (MICs=0.1-5 μg/ml).

HY-N12231

Carbazomycin B	Antibiotic Bacterial Lipoxygenase	Infection Cancer
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM sup>[2]sup>[3]sup>[4].

HY-129548

Prumycin	Others	Infection
Prumycin is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca .

HY-129548A

Prumycin di(hydrochloride)	Others	Infection
Prumycin dihydrochloride is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin dihydrochloride significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin dihydrochloride did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca .

HY-125066

Reveromycin B	Bacterial	Infection
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC₅₀=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.

HY-W014589R

2,4-Di-tert-butylphenol (Standard)	Endogenous Metabolite Fungal Apoptosis	Infection Inflammation/Immunology Cancer
2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol. This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an endogenous metabolite with anti-inflammatory and antioxidant activities and induces the expression of apoptosis genes in cancer cell lines. 2,4-Di-tert-butylphenol also exhibits antiviral and antifungal activities .

HY-W747507

Reveromycin D	Bacterial	Infection
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC₅₀s=1.6 and 1.3 μg/mL, respectively).

HY-113430

5-n-Heneicosylresorcinol 5-Heneicosylresorcinol	Fungal	Infection
5-n-Heneicosylresorcinol (5-Heneicosylresorcinol) is an active n-alkyl(enyl)resorcinols (AR) occurring in cereal products from Colombia. Antifungal activity .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Others	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-N8256

(–)-Mycousnine Mycousunin	Others	Infection
(–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).

HY-134090

9-Methylstreptimidone Antibiotic TS 885; NSC 248958	Bacterial	Infection
9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121362

Evernic Acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Inflammation/Immunology	Bacterial Endogenous Metabolite
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-113219

Hydroxyphenyllactic acid 1 Publications Verification	Infection Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Fungal
Hydroxyphenyllactic acid is an *antifungal* metabolite.

HY-N10215

Canadensolide	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Fungal Endogenous Metabolite
Canadensolide is an antifungal metabolite of Penicillium canadense.

HY-124551

Viridiol	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Fungal Antibiotic
Viridiol, a fungal metabolite from Trichodernza viride, shows antifungal activity .

HY-N10288

Eucalyptacid A	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Endogenous Metabolite
Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM .

HY-N8499

Sporothriolide	Structural Classification Natural Products Microorganisms Source classification	Fungal
Sporothriolide is a metabolite produced by Nodulisporium sp. A21. Sporothriolide has potently antifungal against R. solani and S. sclerotiorum, with EC₅₀ values of 11.6 μM and 10.7 μM, respectively. Sporothriolide inhibits conidium germination of Magnaporthe oryzae in vitro and in vivo .

HY-N10289

Cytosporone C	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Fungal
Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani .

HY-167831

Vermistatin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity .

HY-125723

Echinocandin B SL 7810; A-30912 A	Structural Classification Monophenols Microorganisms Source classification Phenols	Endogenous Metabolite Fungal Antibiotic
Echinocandin B (A 30912) is an antifungal antibiotic and is the secondary metabolite produced by Aspergillus nidulans .

HY-113219R

Hydroxyphenyllactic acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite Fungal
Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.

HY-118118

Phlebiakauranol aldehyde	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite with strong antifungal activity. Phlebiakauranol aldehyde exhibits significant antibacterial and cytotoxic activities against a variety of plant pathogens. The aldehyde group and high number of hydroxyl groups of Phlebiakauranol aldehyde are considered to be the main reasons for its biological activity. The two acetic acid derivatives of Phlebiakauranol aldehyde only exhibit very weak antifungal and antibacterial activities and moderate cytotoxic activity .

HY-N12893

Sclerodione	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal Lipase
Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC₅₀: 1 μM) .

HY-N12260

Benanomicin A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	HIV Bacterial
Benanomicin A is a microbial metabolite and can be isolated from Actinomycetes.Benanomicin has antifungal activitya and inhibits HIV-1 viral infection in MT-4 cells .

HY-100711

Prodigiosin 1 Publications Verification Prodigiosine; NSC47147	Structural Classification Anti-inflammation/Immunoregulatory Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Food Research Infection Microorganisms Antibiotics Pigments Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Apoptosis Wnt Fungal Parasite
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N11528

Eugenitol 7-Noreugenitin	Structural Classification Natural Products Microorganisms Source classification	Others
Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .

HY-N10292

Chaetosemin J	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Fungal Endogenous Metabolite
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .

HY-100711A

Prodigiosin hydrochloride 1 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Pigments Inflammation/Immunology Disease Research Fields Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-125706

1233B	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Antibiotic
1233B is a secondary metabolite from filamentous fungus, Fusarium sp. RK97-94 .

HY-W014589

2,4-Di-tert-butylphenol 1 Publications Verification 2,4-DTBP	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Fungal Apoptosis
2,4-Di-tert-butylphenol (2,4-DTBP) is an endogenous metabolite with anti-inflammatory and antioxidant activities and induces the expression of apoptosis genes in cancer cell lines. 2,4-Di-tert-butylphenol also exhibits antiviral and antifungal activities .

HY-N6780

Ophiobolin B	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Fungal
Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement . The MIC values with the *antifungal* effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL .

HY-N12231

Carbazomycin B	Structural Classification Monophenols Microorganisms Source classification Phenols	Antibiotic Bacterial Lipoxygenase
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM sup>[2]sup>[3]sup>[4].

HY-W014589R

2,4-Di-tert-butylphenol (Standard)	Structural Classification Monophenols Microorganisms Source classification Phenols Endogenous metabolite	Endogenous Metabolite Fungal Apoptosis
2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol. This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an endogenous metabolite with anti-inflammatory and antioxidant activities and induces the expression of apoptosis genes in cancer cell lines. 2,4-Di-tert-butylphenol also exhibits antiviral and antifungal activities .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Structural Classification Flavonoids Microorganisms Xanthones Source classification Phenols Other Flavonoids	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

Cat. No.	Product Name	Chemical Structure

HY-12772S

Hydroxy Itraconazole-d8
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

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antifungal metabolite

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Isotope-Labeled Compounds

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