2. Anti-infection
  3. Fungal
  4. Croconazole

Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .

For research use only. We do not sell to patients.

Croconazole Chemical Structure

Croconazole Chemical Structure

CAS No. : 77175-51-0

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Based on 1 publication(s) in Google Scholar

Croconazole Related Antibodies

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Description

Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile [1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
18.92 μM
Compound: CLOCONAZOLE
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
10.21203/rs.3.rs-23951/v1
Caco-2 CC50
33 μM
Compound: CLOCONAZOLE
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
10.21203/rs.3.rs-23951/v1
Molecular Weight

310.78

Formula

C18H15ClN2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=CC(COC2=C(C(N3C=NC=C3)=C)C=CC=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (402.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2177 mL 16.0886 mL 32.1771 mL
5 mM 0.6435 mL 3.2177 mL 6.4354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2177 mL 16.0886 mL 32.1771 mL 80.4428 mL
5 mM 0.6435 mL 3.2177 mL 6.4354 mL 16.0886 mL
10 mM 0.3218 mL 1.6089 mL 3.2177 mL 8.0443 mL
15 mM 0.2145 mL 1.0726 mL 2.1451 mL 5.3629 mL
20 mM 0.1609 mL 0.8044 mL 1.6089 mL 4.0221 mL
25 mM 0.1287 mL 0.6435 mL 1.2871 mL 3.2177 mL
30 mM 0.1073 mL 0.5363 mL 1.0726 mL 2.6814 mL
40 mM 0.0804 mL 0.4022 mL 0.8044 mL 2.0111 mL
50 mM 0.0644 mL 0.3218 mL 0.6435 mL 1.6089 mL
60 mM 0.0536 mL 0.2681 mL 0.5363 mL 1.3407 mL
80 mM 0.0402 mL 0.2011 mL 0.4022 mL 1.0055 mL
100 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8044 mL
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Croconazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Croconazole77175-51-0Fungalantifungal agentratsimidazole ringInhibitorinhibitorinhibit

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