Search Result
Results for "
antiprotozoal activity
" in MedChemExpress (MCE) Product Catalog:
4
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-B1336
-
-
-
- HY-W079315
-
|
Parasite
|
Infection
|
5-Phenylthieno[2,3-d]pyrimidin-4-amine (Compound 3b) is a heterocyclic compound with antiviral and antiprotozoal activities .
|
-
-
- HY-147857
-
|
Parasite
|
Infection
|
Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 14.9, 21.3 and 9.3 μM, respectively .
|
-
-
- HY-147856
-
|
Parasite
|
Infection
|
Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively .
|
-
-
- HY-B0226A
-
(E)-Nitrofural
|
Bacterial
Parasite
|
Infection
|
(E)-Nitrofurazone ((E)-Nitrofural) is a topical broad-spectrum antibacterial agent effective against both Gram-negative and Gram-positive bacteria. (E)-Nitrofurazone also possesses antiprotozoal and antiparasitic activities. (E)-Nitrofurazone is commonly used in the research of superficial wounds, burns, skin infections, pyoderma, infectious skin diseases, trypanosomiasis, and acute bacillary dysentery .
|
-
-
- HY-N6587
-
Methyl betulinate
|
Parasite
|
Others
|
Betulinic acid methyl ester, a betulinic acid derivative, possesses antiprotozoal activity .
|
-
-
- HY-165123
-
|
Fungal
Parasite
|
Infection
|
Mepartricin is a polyene macrolide with antifungal and antiprotozoal activities, widely used in research related to benign prostatic hyperplasia .
|
-
-
- HY-118996A
-
|
Parasite
|
Infection
|
Isometamidium chloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride can be used in research of african sleeping sickness .
|
-
-
- HY-N10255
-
|
Parasite
|
Infection
|
Trypacidin is the conidia-bound metabolite with antiprotozoal activity. Trypacidin has a protective function against phagocytes both in the environment and during the infection process .
|
-
-
- HY-P5696
-
|
Bacterial
Parasite
Fungal
|
Infection
|
Xenopsin precursor fragment is an antimicrobial peptide, and has antibacterial/antifungal (10-500 μg/mL) and anti-protozoal (MIC: 2-20 μg/mL) activity .
|
-
-
- HY-N11173
-
|
Others
|
Metabolic Disease
|
cis-Melilotoside, an o-Coumaric acid derivative, shows potent antioxidant activity. cis-Melilotoside has antiprotozoal activity moderately against T. cruzi with an IC50 of 78.2 ug/mL .
|
-
-
- HY-17008
-
Ponazuril
|
Parasite
|
Infection
|
Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry .
|
-
-
- HY-115249
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa .
|
-
-
- HY-101590A
-
L 16726 dihydrochloride
|
Parasite
|
Infection
|
Symetine dihydrochloride (L 16726 dihydrochloride) is the dihydrochloride form of Symetine (HY-101590). Symetine dihydrochloride exhibits antiprotozoal activity aginst Entamoeba histolytica, and ameliorates the amebic liver abscess in guinea pig model .
|
-
-
- HY-N0914
-
Ajugol
2 Publications Verification
|
Parasite
|
Others
|
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC50 of 31.8 μg/mL .
|
-
-
- HY-W040073
-
|
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-101848
-
|
Fungal
|
Infection
|
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .
|
-
-
- HY-G0016
-
MADDS; Monoacetyldapsone
|
Drug Metabolite
|
Others
|
N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities .
|
-
-
- HY-B1336R
-
|
Bacterial
Apoptosis
Antibiotic
Parasite
|
Infection
Cancer
|
Furazolidone (Standard) is the analytical standard of Furazolidone. This product is intended for research and analytical applications. Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. It inhibits AML1-ETO transformed cells with an IC50 of 12.7 μM.
|
-
-
- HY-N7632
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively .
|
-
-
- HY-W040073S
-
|
Isotope-Labeled Compounds
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-B0295
-
|
Bacterial
Antibiotic
Parasite
|
Infection
|
Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp .
|
-
-
- HY-N9179
-
|
Parasite
|
Infection
|
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL) .
|
-
-
- HY-119604
-
|
Antibiotic
Bacterial
|
Infection
|
Cafamycin is a polyether antibiotic active against gram-positive bacteria, including Staphylococcus aureus. Cafamycin also demonstrates insecticidal and antiprotozoal activities. Cafamycin is isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin .
|
-
-
- HY-N7516
-
|
Parasite
Bacterial
Fungal
|
Infection
|
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .
|
-
-
- HY-W040073R
-
|
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox (Standard) is the analytical standard of Nifurtimox. This product is intended for research and analytical applications. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-N10547
-
|
Parasite
|
Infection
|
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC50: 32.5 and 8.3 μg/mL) .
|
-
-
- HY-N0914R
-
|
Parasite
|
Others
|
Ajugol (Standard) is the analytical standard of Ajugol. This product is intended for research and analytical applications. Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC50 of 31.8 μg/mL .
|
-
-
- HY-17008R
-
|
Parasite
|
Infection
|
Toltrazuril (sulfone) (Standard) is the analytical standard of Toltrazuril (sulfone). This product is intended for research and analytical applications. Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry .
|
-
-
- HY-115249R
-
|
Parasite
Antibiotic
Bacterial
|
Infection
|
Metronidazole acetic acid (Standard) is the analytical standard of Metronidazole acetic acid. This product is intended for research and analytical applications. Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa .
|
-
-
- HY-147766
-
|
Parasite
|
Infection
|
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .
|
-
-
- HY-P2450
-
Antibiotic P168
|
Fungal
Antibiotic
|
Infection
Cancer
|
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
|
-
-
- HY-146487
-
|
Bacterial
Parasite
|
Infection
|
Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .
|
-
-
- HY-B0688
-
Dapsone
1 Publications Verification
4,4′-Diaminodiphenyl sulfone; DDS
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
|
-
-
- HY-155281
-
|
Parasite
|
Infection
|
Antiparasitic agent-18 (compound 3a) is active and selective against the T. brucei (EC50=0.4 μM), T. cruzi (EC50=0.21 μM), and L. donovani (EC50=0.26 μM). Antiparasitic agent-18 has potent antiprotozoal activity .
|
-
-
- HY-B0295R
-
|
Bacterial
Antibiotic
Parasite
|
Infection
|
Chloroxine (Standard) is the analytical standard of Chloroxine. This product is intended for research and analytical applications. Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp .
|
-
-
- HY-B0688S1
-
4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
|
-
-
- HY-B0740
-
MK130 hydrochloride
|
5-HT Receptor
Parasite
|
Infection
Neurological Disease
|
Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
|
-
-
- HY-168619
-
|
Parasite
|
Infection
Cancer
|
DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei .
|
-
-
- HY-B0688R
-
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
|
-
-
- HY-B0740R
-
MK130 hydrochloride (Standard)
|
5-HT Receptor
|
Neurological Disease
|
Cyclobenzaprine (MK130) hydrochloride (Standard) is the analytical standard of Cyclobenzaprine (MK130) hydrochloride. This product is intended for research and analytical applications. Cyclobenzaprine hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
|
-
-
- HY-B0688S2
-
4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
|
Isotope-Labeled Compounds
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
|
-
-
- HY-A0059
-
NF 113; SAP 113; Methylmercadone
|
Bacterial
Parasite
Antibiotic
Fungal
Apoptosis
STAT
Interleukin Related
TNF Receptor
|
Infection
Inflammation/Immunology
Cancer
|
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
|
-
-
- HY-B0740S3
-
MK130-d3-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Parasite
|
Infection
Neurological Disease
|
Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
|
-
-
- HY-130743
-
Bis-eugenol; Dehydrodieugenol
|
Parasite
|
Infection
|
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
|
-
Cat. No. |
Product Name |
Target |
Research Area |
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0914
-
-
-
- HY-101848
-
-
-
- HY-N7632
-
-
-
- HY-N7516
-
-
-
- HY-N6587
-
-
-
- HY-N10255
-
-
-
- HY-N11173
-
-
-
- HY-N9179
-
|
Infection
Flavonoids
Classification of Application Fields
Flavones
Source classification
Lupinus perennis L.
Plants
Compositae
Disease Research Fields
|
Parasite
|
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL) .
|
-
-
- HY-119604
-
-
-
- HY-N10547
-
-
-
- HY-N0914R
-
-
-
- HY-P2450
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W040073S
-
|
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-B0688S1
-
|
Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
|
-
-
- HY-B0688S2
-
|
Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
|
-
-
- HY-B0740S3
-
|
Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
|
-
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: