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Results for "

chitin synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Endogenous Metabolite (1) Fungal (19)
By Research Areas:	Cancer (4) Infection (17) Inflammation/Immunology (3)

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Targets Recommended: PGE synthase Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151419

Chitin synthase inhibitor 9	Fungal	Infection
Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .

HY-151418

Chitin synthase inhibitor 8	Fungal	Infection
Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .

HY-151417

Chitin synthase inhibitor 7	Fungal	Infection
Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC₅₀ value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .

HY-151416

Chitin synthase inhibitor 6	Fungal	Infection
Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC₅₀ value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .

HY-149585

Chitin synthase inhibitor 14	Fungal	Infection
Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants .

HY-150584

Chitin synthase inhibitor 3	Fungal	Infection
Chitin synthase inhibitor 3 (compound 2d) is a potent **chitin synthase inhibitor with an IC₅₀** value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .

HY-151421

Chitin synthase inhibitor 11	Fungal	Infection Cancer
Chitin synthase inhibitor 11 is a **chitin synthase** inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .

HY-150583

Chitin synthase inhibitor 2	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of **chitin synthase with the IC₅₀** value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .

HY-151420

Chitin synthase inhibitor 10	Fungal	Infection Cancer
Chitin synthase inhibitor 10 is a **chitin synthase** inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .

HY-151422

Chitin synthase inhibitor 12	Fungal	Infection Cancer
Chitin synthase inhibitor 12 is a **chitin synthase** inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC₅₀ value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .

HY-150686

Chitin synthase inhibitor 4	Fungal	Infection
Chitin synthase inhibitor 4 (compound 4fh) is a **chitin synthase inhibitor with fungicidal** effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture .

HY-155569

Chitin synthase inhibitor 13	Fungal	Infection
Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of **chitin synthase, with an IC₅₀** of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity .

HY-151410

Chitin synthase inhibitor 5	Fungal	Infection
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of **chitin synthase with an IC₅₀** value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .

HY-144391

Chitin synthase inhibitor 1	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC₅₀=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants .

HY-19593

Nikkomycin Z	Fungal Antibiotic	Infection
Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine .

HY-103027

Polyoxin B 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid	Fungal	Infection Inflammation/Immunology
Polyoxin B is a potent **chitin synthase inhibitor (IC₅₀**=0.08 mM) and an effective antifungal agent .

HY-125916

Pseurotin A	Endogenous Metabolite	Cancer
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of **chitin synthase** and a neuritogenic agent. Pseurotin A inhibits IgE production (IC₅₀=3.6 μM). Antitumor activity .

HY-N8512

Asperfuran	Fungal	Infection
Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC₅₀ of 25 μg/ml .

HY-168108

Antifungal agent 115	Fungal	Infection
Antifungal agent 115 (compound 8n) is a non-competitive chitin synthase (CHS) inhibitor with an IC₅₀ of 93 μM. Antifungal agent 115 demonstrates good selectivity and broad-spectrum antifungal activity, exhibiting significant efficacy against drug-resistant fungi. Antifungal agent 115 can be utilized in fungi infection research .

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Fungal	Infection
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

Cat. No.	Product Name	Type

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Cell Assay Reagents
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

Polyoxin B 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid	Classification of Application Fields Inflammation/Immunology Disease Research Fields	Fungal
Polyoxin B is a potent **chitin synthase inhibitor (IC₅₀**=0.08 mM) and an effective antifungal agent .

Pseurotin A	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of **chitin synthase** and a neuritogenic agent. Pseurotin A inhibits IgE production (IC₅₀=3.6 μM). Antitumor activity .

Asperfuran	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields	Fungal
Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC₅₀ of 25 μg/ml .

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chitin synthase

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