Chitin synthase inhibitor 11 

Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs)^[1].

IC50: 0.10 mM (chitin synthase)^[1]
MIC: 128 μg/mL (C. albicans); 42.67 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)^[1]

Chitin synthase inhibitor 11 (compound 9s) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC₅₀ value of 0.10 mM^[1].
Chitin synthase inhibitor 11 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 128μg/mL, 42.67 μg/mL, 64 μg/mL and 64 μg/mL, respectively^[1].
Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.47

C₂₄H₂₄N₄O₈

2725075-04-5

O=C(NC1=CC=C([N+]([O-])=O)C=C1OC)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723  [Content Brief]