Polyoxin B  (Synonyms: 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid)

Polyoxin B is a potent chitin synthase inhibitor (IC₅₀=0.08 mM) and an effective antifungal agent^[1].

IC50: chitin synthase^[1]

Polyoxin B has anti-fungi effects in vitro, the MIC values are 32 μg/ml, 64 μg/ml, 64 μg/ml and 8 μg/ml, respectively against Candida albicans, Aspergillus flavus, Aspergillums fumigatus, and Cryptococcus neoformans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

507.41

C₁₇H₂₅N₅O₁₃

19396-06-6

O[C@H]1[C@H](N(C(N2)=O)C=C(CO)C2=O)O[C@H]([C@H](NC([C@@H](N)[C@@H]([C@H](COC(N)=O)O)O)=O)C(O)=O)[C@H]1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mi-Young Yoon, et al. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6  [Content Brief]

  [2]. Qinggang Ji, et al. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176  [Content Brief]