2. Anti-infection
  3. Fungal
  4. Chitin synthase inhibitor 4

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.

For research use only. We do not sell to patients.

Chitin synthase inhibitor 4 Chemical Structure

Chitin synthase inhibitor 4 Chemical Structure

CAS No. : 2755847-31-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 181 In-stock
Solution
10 mM * 1 mL in DMSO USD 181 In-stock
Solid
5 mg USD 165 In-stock
10 mg USD 290 In-stock
25 mg USD 590 In-stock
50 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Chitin synthase inhibitor 4 Related Antibodies

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Description

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture[1].

In Vitro

Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively[1].
Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectively[1].
Chitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis[1].
Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chitin synthase inhibitor 4 Related Antibodies
In Vivo

Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity [1].
Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat with Salmonella typhimurium[1]
Dosage: As Acute Oral Toxicity for Chemicals-Acute Toxic Class Method
Administration: Oral gavage
Result: Showed acute toxicity of 3.58 as toxicity grading standard, and negative carcinogenic toxicity, negative mutagenic toxicity.
Molecular Weight

346.36

Formula

C20H15FN4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=CC=C1OC2=NC=NC(N3CCCC4=C3C=CC=C4)=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (288.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8872 mL 14.4358 mL 28.8717 mL
5 mM 0.5774 mL 2.8872 mL 5.7743 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8872 mL 14.4358 mL 28.8717 mL 72.1792 mL
5 mM 0.5774 mL 2.8872 mL 5.7743 mL 14.4358 mL
10 mM 0.2887 mL 1.4436 mL 2.8872 mL 7.2179 mL
15 mM 0.1925 mL 0.9624 mL 1.9248 mL 4.8119 mL
20 mM 0.1444 mL 0.7218 mL 1.4436 mL 3.6090 mL
25 mM 0.1155 mL 0.5774 mL 1.1549 mL 2.8872 mL
30 mM 0.0962 mL 0.4812 mL 0.9624 mL 2.4060 mL
40 mM 0.0722 mL 0.3609 mL 0.7218 mL 1.8045 mL
50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4436 mL
60 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2030 mL
80 mM 0.0361 mL 0.1804 mL 0.3609 mL 0.9022 mL
100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.7218 mL
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Chitin synthase inhibitor 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chitin synthase inhibitor 42755847-31-3Chitin synthase inhibitor4Chitin synthase inhibitor-4Fungalpyrimidine ether scaffold1,2,3,4-tetrahydroquinolineantifungal activityfungicidepolyoxin DSclerotinia sclerotiorumValsa maliInhibitorinhibitorinhibit

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