Chitin synthase inhibitor 10 

Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs)^[1].

IC50: 0.11 mM (chitin synthase)^[1]
MIC: 64 μg/mL (C. albicans); 256 μg/mL (A. flavus); 128 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)^[1]

Chitin synthase inhibitor 10 (compound 9o) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC₅₀ value of 0.11 mM^[1].
Chitin synthase inhibitor 10 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 256 μg/mL, 128 μg/mL and 64 μg/mL, respectively^[1].
Chitin synthase inhibitor 10 is related to the disruption of cell wall architecture^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

609.26

C₂₄H₂₃Br₂N₃O₆

2725075-01-2

O=C(NC1=C(Br)C=C(OC)C=C1Br)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723.  [Content Brief]