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functional dyspepsia

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By Targets:	5-HT Receptor (4) Cholinesterase (ChE) (5) Dopamine Receptor (4) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) NO Synthase (1)
By Research Areas:	Inflammation/Immunology (4) Metabolic Disease (9) Neurological Disease (4)

13

Inhibitors & Agonists

2

Natural
Products

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Acotiamide monohydrochloride trihydrate	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC₅₀ of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

L-Arginine (L-glutamate) 5+ Cited Publications (S)-(+)-Arginine (L-glutamate)	Endogenous Metabolite NO Synthase	Metabolic Disease
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .

Cinitapride monotartrate	5-HT Receptor Dopamine Receptor	Neurological Disease
Cinitapride monotartrate is a 5-HT_1A and 5-HT₄ agonist. Cinitapride monotartrate is also a 5-HT_2A and D₂ antagonist. Cinitapride monotartrate can be used for the research of functional dyspepsia .

Acotiamide hydrochloride Z-338; YM443	Cholinesterase (ChE)	Others Metabolic Disease Inflammation/Immunology
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

Acotiamide Z-338 free base; YM443 free base	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology
Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

Acotiamide monohydrochloride trihydrate (Standard)	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology
Acotiamide (monohydrochloride trihydrate) (Standard) is the analytical standard of Acotiamide (monohydrochloride trihydrate). This product is intended for research and analytical applications. Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC₅₀ of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

Acotiamide-d6 Z-338-d₆ free base; YM443-d₆ free base	Isotope-Labeled Compounds Cholinesterase (ChE)	Metabolic Disease
Acotiamide-d₆ is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia[1][2].

Magnoloside A	Others	Others
Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .

R-137696	5-HT Receptor	Others
R-137696 is an orally active serotonin-1A (5-HT_1A) receptor agonist which relaxes the proximal stomach. R-137696 can be utilized in research related to functional dyspepsia .

Bromopride hydrochloride	Dopamine Receptor	Neurological Disease
Bromopride hydrochloride is a prokinetic drug with antiemetic activity. Bromopride hydrochloride is used to suppress nausea and vomiting, especially in the management of upper gastrointestinal dysmotility. Bromopride hydrochloride, as a dopamine D2 receptor antagonist, is clinically used to suppress functional dyspepsia, gastric retention and vomiting caused by various reasons .

Cinitapride	5-HT Receptor Dopamine Receptor	Neurological Disease Metabolic Disease
Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research .

Cinitapride (Standard)	5-HT Receptor Dopamine Receptor	Neurological Disease Metabolic Disease
Cinitapride (Standard) is the analytical standard of Cinitapride. This product is intended for research and analytical applications. Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research .

Aldioxa	Others	Metabolic Disease
Aidioxa has the ability to improve delayed gastric emptying in rats. It can partially improve delayed gastric emptying caused by clonidine or restraint stress. The allyltoin part of Aidioxa restores gastric emptying activity by antagonizing α-2 adrenergic receptors. Its aluminum hydroxide part is involved in restoring gastric compliance. Aidioxa can improve both delayed gastric emptying and impaired gastric compliance, both of which play an important role in functional dyspepsia (FD). Aidioxa is a candidate agent for inhibiting FD.

Cat. No.	Product Name	Category	Target	Chemical Structure

L-Arginine (L-glutamate) 5+ Cited Publications (S)-(+)-Arginine (L-glutamate)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite NO Synthase
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .

Magnoloside A	Structural Classification Magnolia officinalis. Rehd. et Wils. Source classification Magnoliaceae Phenols Polyphenols Plants	Others
Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .

Cat. No.	Product Name	Chemical Structure

Acotiamide-d6
Acotiamide-d₆ is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia[1][2].

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