2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acotiamide

Acotiamide  (Synonyms: Z-338 free base; YM443 free base)

Cat. No.: HY-121467
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Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

For research use only. We do not sell to patients.

Acotiamide Chemical Structure

Acotiamide Chemical Structure

CAS No. : 185106-16-5

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Based on 1 publication(s) in Google Scholar

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Acotiamide Related Antibodies

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Description

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

IC50 & Target

IC50: 1.79 μM (AChE)[3].
In Vitro

Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acotiamide Related Antibodies

Cell Viability Assay[1]

Cell Line: NR8383, macrophage
Concentration: 10, 30, 100 μM
Incubation Time: 1 hour
Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.
In Vivo

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage: 0.3, 1, 3, 10, 30 mg/kg
Administration: Intravenous injection; once
Result: Increased the postprandial gastric motility.
Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks)[3]
Dosage: 0.83 mg/kg
Administration: Intravenous injection; once.
Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
Clinical Trial
Molecular Weight

450.55

Formula

C21H30N4O5S
CAS No.
SMILES

O=C(C1=CSC(NC(C2=CC(OC)=C(OC)C=C2O)=O)=N1)NCCN(C(C)C)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Acotiamide Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acotiamide185106-16-5Z-338YM443Z338Z 338YM 443YM-443Cholinesterase (ChE)gastric motilityfunctional dyspepsiaNR8383macrophageintestinal inflammatorygastric emptyingInhibitorinhibitorinhibit

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