2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acotiamide

Acotiamide  (Synonyms: Z-338 free base; YM443 free base)

Cat. No.: HY-121467 Purity: 99.92%
SDS
COA
Handling Instructions Technical Support

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

For research use only. We do not sell to patients.

Acotiamide Chemical Structure

Acotiamide Chemical Structure

CAS No. : 185106-16-5

Size Price Stock Quantity
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acotiamide:

Acotiamide Related Antibodies

Top Publications Citing Use of Products

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

IC50 & Target

IC50: 1.79 μM (AChE)[3].
In Vitro

Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acotiamide Related Antibodies

Cell Viability Assay[1]

Cell Line: NR8383, macrophage
Concentration: 10, 30, 100 μM
Incubation Time: 1 hour
Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.
In Vivo

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage: 0.3, 1, 3, 10, 30 mg/kg
Administration: Intravenous injection; once
Result: Increased the postprandial gastric motility.
Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks)[3]
Dosage: 0.83 mg/kg
Administration: Intravenous injection; once.
Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
Clinical Trial
Molecular Weight

450.55

Formula

C21H30N4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CSC(NC(C2=CC(OC)=C(OC)C=C2O)=O)=N1)NCCN(C(C)C)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (554.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2195 mL 11.0975 mL 22.1951 mL
5 mM 0.4439 mL 2.2195 mL 4.4390 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2195 mL 11.0975 mL 22.1951 mL 55.4877 mL
5 mM 0.4439 mL 2.2195 mL 4.4390 mL 11.0975 mL
10 mM 0.2220 mL 1.1098 mL 2.2195 mL 5.5488 mL
15 mM 0.1480 mL 0.7398 mL 1.4797 mL 3.6992 mL
20 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7744 mL
25 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
30 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8496 mL
40 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
50 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1098 mL
60 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9248 mL
80 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
100 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5549 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Acotiamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acotiamide185106-16-5Z-338YM443Z338Z 338YM 443YM-443Cholinesterase (ChE)gastric motilityfunctional dyspepsiaNR8383macrophageintestinal inflammatorygastric emptyingInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Acotiamide
Cat. No.:
HY-121467
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.