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methionine aminopeptidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (2) MetAP (6) Amino Acid Derivatives (1) Bacterial (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (1)

12

Inhibitors & Agonists

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4

Recombinant Proteins

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Antibodies

Targets Recommended: Aminopeptidase MetAP Methionine Adenosyltransferase (MAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TP-004	MetAP	Metabolic Disease
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC₅₀ of 6 nM .

TNP-470 1 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a **methionine aminopeptidase-2 inhibitor and also an angiogenesis** inhibitor.

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

Relzomostat	MetAP	Metabolic Disease
Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity .

OJT008	Bacterial	Infection
OJT008 is an inhibitor of MtMetAP1c. OJT008 inhibits NiCl₂- and CoCl₂ activated MtMetAP1c with IC₅₀s of 11 and 40 μM, respectively. OJT008 can used to study tuberculosis .

SDX-7539	MetAP	Cancer
SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC₅₀ of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice .

Adamantanine 2-Aminoadamantane-2-carboxylic acid	Aminopeptidase	Cancer
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5 .

Lys-psi(CH2NH)-Trp(Nps)-OMe LTNAM	Others	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

Cat. No.	Product Name	Target	Research Area

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

Species:	Human (3) Mouse (1)
Tag:	His (3) Tag Free (1)
Source:	Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	*METAP1/Methionine* aminopeptidase 1 Protein, Human** rHumethionine aminopeptidase 1/METAP1; methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1	Human	E. coli
	METAP1 (or methionine aminopeptidase 1) plays a crucial role in protein synthesis by co-translationally removing N-terminal methionine from nascent proteins.This enzymatic activity is particularly relevant when the second residue in the primary sequence is small and uncharged (including residues such as Ala, Cys, Gly, Pro, Ser, Thr or Val).METAP1/Methionine aminopeptidase 1 Protein, Human is the recombinant human-derived METAP1/Methionine aminopeptidase 1 protein, expressed by E.coli , with tag free.

	*METAP2/Methionine* aminopeptidase 2 Protein, Human (Sf9, His)** rHumethionine aminopeptidase 2/METAP2, His; methionine aminopeptidase 2; MAP 2; MetAP 2; p67; p67eIF2; Peptidase M; METAP2; MAP2	Human	Sf9 insect cells
	METAP2/Methionine aminopeptidase 2 protein removes N-terminal methionine from nascent proteins. It preferentially cleaves when the second residue is small and uncharged. METAP2 has higher catalytic activity for Met-Val peptides than METAP1, suggesting its role in processing Met-Val and Met-Thr sequences in vivo. It also protects EIF2S1 from phosphorylation by inhibitory kinases, regulating protein synthesis. METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells , with N-6*His labeled tag.

	*METAP2/Methionine* aminopeptidase 2 Protein, Mouse (sf9, His)** methionine aminopeptidase 2; MAP 2; p67eIF2; Peptidase M; Mnpep	Mouse	Sf9 insect cells
	METAP2, also known as methionine aminopeptidase 2, plays a critical role in protein synthesis by co-translationally removing N-terminal methionine from nascent proteins. This enzymatic activity is particularly pronounced when the second residue in the primary sequence is small and uncharged (including residues such as Ala, Cys, Gly, Pro, Ser, Thr, or Val). METAP2/Methionine aminopeptidase 2 Protein, Mouse (sf9, His) is the recombinant mouse-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of METAP2/Methionine aminopeptidase 2 Protein, Mouse (sf9, His) is 477 a.a., with molecular weight of ~60 kDa.

	*METAP1D/Methionine* aminopeptidase 1D Protein, Human (His)** methionine aminopeptidase 1D Mitochondrial; Methionyl aminopeptidase Type 1D Mitochondrial; METAP1D; MAP1D	Human	E. coli
	METAP1D or methionine aminopeptidase 1D plays a crucial role in protein maturation, catalyzing the removal of N-terminal methionine from nascent proteins. Its activity is prominent in the smaller, uncharged second residue (Met-Ala, Cys, Gly, Pro, Ser, Thr or Val). METAP1D/Methionine aminopeptidase 1D Protein, Human (His) is the recombinant human-derived METAP1D/Methionine aminopeptidase 1D protein, expressed by E. coli , with N-6His, C-6His labeled tag. The total length of METAP1D/Methionine aminopeptidase 1D Protein, Human (His) is 292 a.a., with molecular weight of 35-40 kDa.

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	Methionine Aminopeptidase 2 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Methionine Aminopeptidase 2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 53 kDa, targeting to Methionine Aminopeptidase 2. It can be used for WB,ICC,IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

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